TY  - GEN
N2  - The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons that occurs at special cellular junctions called synapses. During brain development, distinct types of neurons must identify each other to form synaptic connections. In this dissertation, I use mouse genetic tools to study the role of dystroglycan at inhibitory synapses in the forebrain. I show that CCK+ interneurons are present in the brains of mice that lack dystroglycan from the nervous system, but their axons are distributed abnormally in the hippocampus. These findings have important implications for understanding the molecular mechanisms that neurons use to wire together during brain development.
DO  - 10.6083/pz50gw768
DO  - DOI
AB  - The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons that occurs at special cellular junctions called synapses. During brain development, distinct types of neurons must identify each other to form synaptic connections. In this dissertation, I use mouse genetic tools to study the role of dystroglycan at inhibitory synapses in the forebrain. I show that CCK+ interneurons are present in the brains of mice that lack dystroglycan from the nervous system, but their axons are distributed abnormally in the hippocampus. These findings have important implications for understanding the molecular mechanisms that neurons use to wire together during brain development.
T1  - The role of dystroglycan in interneuron development
DA  - 2021
AU  - Miller, Daniel S.
L1  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9283
L4  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
KW  - Interneurons
KW  - Apoptosis
KW  - Dystroglycans
KW  - Axons
KW  - Synapses
TI  - The role of dystroglycan in interneuron development
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
ER  -