TY  - GEN
AB  - The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons that occurs at special cellular junctions called synapses. During brain development, distinct types of neurons must identify each other to form synaptic connections. In this dissertation, I use mouse genetic tools to study the role of dystroglycan at inhibitory synapses in the forebrain. I show that CCK+ interneurons are present in the brains of mice that lack dystroglycan from the nervous system, but their axons are distributed abnormally in the hippocampus. These findings have important implications for understanding the molecular mechanisms that neurons use to wire together during brain development.
AD  - Oregon Health and Science University
AU  - Miller, Daniel S.
DA  - 2021
DO  - 10.6083/pz50gw768
DO  - DOI
ED  - Wright, Kevin
ED  - Nechiporuk, Alex
ED  - Schnell, Eric
ED  - Copenhaver, Philip
ED  - Logan, Mary
ED  - Advisor
ED  - Committee chair
ED  - Committee member
ED  - Committee member
ED  - Committee member
ID  - 9283
KW  - Interneurons
KW  - Apoptosis
KW  - Dystroglycans
KW  - Axons
KW  - Synapses
L1  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
L2  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
L4  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
N2  - The brain is a dense network of precisely interconnected cells called neurons. Our thoughts and behaviors require communication between billions of individual neurons that occurs at special cellular junctions called synapses. During brain development, distinct types of neurons must identify each other to form synaptic connections. In this dissertation, I use mouse genetic tools to study the role of dystroglycan at inhibitory synapses in the forebrain. I show that CCK+ interneurons are present in the brains of mice that lack dystroglycan from the nervous system, but their axons are distributed abnormally in the hippocampus. These findings have important implications for understanding the molecular mechanisms that neurons use to wire together during brain development.
PB  - Oregon Health and Science University
PY  - 2021
T1  - The role of dystroglycan in interneuron development
TI  - The role of dystroglycan in interneuron development
UR  - https://digitalcollections.ohsu.edu/record/9283/files/Miller.Daniel.2021.pdf
Y1  - 2021
ER  -