000009285 001__ 9285
000009285 005__ 20231129124949.0
000009285 0247_ $$2DOI$$a10.6083/37720d444
000009285 037__ $$aETD
000009285 245__ $$aThe role, function, and generation of Eomeshi CD8+ T Cells in OX40 and CTLA-4 targeted cancer immunotherapy
000009285 260__ $$bOregon Health and Science University
000009285 269__ $$a2021
000009285 336__ $$aThesis
000009285 502__ $$bPh.D.
000009285 520__ $$aMonoclonal antibodies targeting key receptors that inhibit T cell function such as CTLA-4 and PD-1 have demonstrated the potency of checkpoint blockade, highlighted by long-term complete responses for metastatic cancers once thought incurable. However, only a subset of patients will respond to checkpoint blockade due to a multitude of factors including an immunosuppressive tumor microenvironment and the mutational burden of the cancer.
000009285 650__ $$aNeoplasms$$022758
000009285 650__ $$aCD8-Positive T-Lymphocytes$$030782
000009285 650__ $$aImmunotherapy$$020724
000009285 6531_ $$aibrutinib
000009285 691__ $$aSchool of Medicine$$041369
000009285 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422
000009285 7001_ $$aEmerson, Dana
000009285 8564_ $$90cf79c71-0403-469e-b5df-3c39c5573232$$s3657054$$uhttps://digitalcollections.ohsu.edu/record/9285/files/Emerson.Dana.2021.pdf
000009285 905__ $$a/rest/prod/37/72/0d/44/37720d444
000009285 909CO $$ooai:digitalcollections.ohsu.edu:9285$$pstudent-work
000009285 980__ $$aTheses and Dissertations