TY - GEN N2 - Opioids such as morphine, oxycodone, and fentanyl effectively relieve acute and post-operative pain, but long-term use can lead to tolerance. Chronic opioid use leads to cellular and circuit level adaptations that mediate tolerance, but how different opioids can differentially regulate the activity of the opioid receptor (MOR) and downstream effectors is not known. The goal of this dissertation is to advance our understanding of tolerance induced by opioids in both the somatodendritic and presynaptic terminal compartments. DO - 10.6083/w37637670 DO - DOI AB - Opioids such as morphine, oxycodone, and fentanyl effectively relieve acute and post-operative pain, but long-term use can lead to tolerance. Chronic opioid use leads to cellular and circuit level adaptations that mediate tolerance, but how different opioids can differentially regulate the activity of the opioid receptor (MOR) and downstream effectors is not known. The goal of this dissertation is to advance our understanding of tolerance induced by opioids in both the somatodendritic and presynaptic terminal compartments. T1 - Adaptations following chronic opioid treatment in the presynpatic and postsynaptic compartments of neurons DA - 2021 AU - Adhikary, Sweta L1 - https://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf PB - Oregon Health and Science University PY - 2021 ID - 9286 L4 - https://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf KW - Adenylyl Cyclases KW - Phosphorylation KW - Adenosine KW - Drug Tolerance KW - Presynaptic Terminals KW - opioid analgesics TI - Adaptations following chronic opioid treatment in the presynpatic and postsynaptic compartments of neurons Y1 - 2021 L2 - https://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf LK - https://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf UR - https://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf ER -