000009286 001__ 9286
000009286 005__ 20240124114320.0
000009286 0247_ $$2DOI$$a10.6083/w37637670
000009286 037__ $$aETD
000009286 245__ $$aAdaptations following chronic opioid treatment in the presynpatic and postsynaptic compartments of neurons
000009286 260__ $$bOregon Health and Science University
000009286 269__ $$a2021
000009286 336__ $$aDissertation
000009286 502__ $$bPh.D.
000009286 520__ $$aOpioids such as morphine, oxycodone, and fentanyl effectively relieve acute and post-operative pain, but long-term use can lead to tolerance. Chronic opioid use leads to cellular and circuit level adaptations that mediate tolerance, but how different opioids can differentially regulate the activity of the opioid receptor (MOR) and downstream effectors is not known. The goal of this dissertation is to advance our understanding of tolerance induced by opioids in both the somatodendritic and presynaptic terminal compartments.
000009286 542__ $$fIn copyright - single owner
000009286 650__ $$aAdenylyl Cyclases$$014255
000009286 650__ $$aPhosphorylation$$024067
000009286 650__ $$aAdenosine$$014235
000009286 650__ $$aDrug Tolerance$$018089
000009286 650__ $$aPresynaptic Terminals$$030195
000009286 6531_ $$aopioid analgesics
000009286 691__ $$aSchool of Medicine$$041369
000009286 692__ $$aVollum Institute$$041509
000009286 7001_ $$aAdhikary, Sweta
000009286 8564_ $$97d3ea396-41bf-4a02-9971-020dc69710e5$$s5183154$$uhttps://digitalcollections.ohsu.edu/record/9286/files/Adhikary.Sweta.2021.pdf
000009286 905__ $$a/rest/prod/w3/76/37/67/w37637670
000009286 909CO $$ooai:digitalcollections.ohsu.edu:9286$$pstudent-work
000009286 980__ $$aTheses and Dissertations