000009293 001__ 9293
000009293 005__ 20231129124948.0
000009293 0247_ $$2DOI$$a10.6083/x346d491q
000009293 037__ $$aETD
000009293 245__ $$aStain by numbers: toward the next generation of biomarkers in cancer systems biology
000009293 260__ $$bOregon Health and Science University
000009293 269__ $$a2021
000009293 336__ $$aDissertation
000009293 502__ $$bPh.D.
000009293 520__ $$aCancers are complex diseases that operate at multiple biological scales - from atom to organism - and the purview of cancer systems biology is to integrate information between scales to derive insight into their mechanisms and therapeutic vulnerabilities. From this holistic perspective, the field has come to appreciate that the spatial context of the tumor microenvironment in intact tissues not only enables a more granular definition of disease, but also the design of more personalized and effective therapies. In spite of this promise, spatial context-preserving cytometry paradigms like multiplex tissue imaging (MTI) are beset with many challenges related to cost, computational complexity, and study design. The discovery and development of the next generation of biomarkers in cancer systems biology will require computational tools which can cope with the increasing scale and complexity of our measurements, and the work we share within serves as a step toward achieving that requirement.
000009293 542__ $$fIn copyright - single owner
000009293 650__ $$aTumor Microenvironment$$039473
000009293 650__ $$aNeoplasms$$022758
000009293 650__ $$aArtificial Intelligence$$015109
000009293 650__ $$aSystems Biology$$036214
000009293 650__ $$aMachine Learning$$011449
000009293 691__ $$aSchool of Medicine$$041369
000009293 692__ $$aDepartment of Biomedical Engineering$$041397
000009293 7001_ $$aBurlingame, Erik A.
000009293 8564_ $$9f0108c93-43ff-48da-821d-01d82250144d$$s66956611$$uhttps://digitalcollections.ohsu.edu/record/9293/files/Burlingame.Erik.2021.pdf
000009293 905__ $$a/rest/prod/x3/46/d4/91/x346d491q
000009293 909CO $$ooai:digitalcollections.ohsu.edu:9293$$pstudent-work
000009293 980__ $$aTheses and Dissertations