000009304 001__ 9304
000009304 005__ 20240124114320.0
000009304 0247_ $$2DOI$$a10.6083/w0892b788
000009304 037__ $$aETD
000009304 245__ $$aA genetic approach to understanding  axonal mitochondrial biology
000009304 260__ $$bOregon Health and Science University
000009304 269__ $$a2021
000009304 336__ $$aDissertation
000009304 502__ $$bPh.D.
000009304 520__ $$aMitochondria are essential organelles for all cell types, especially for neurons, which possess extremely long axons that require the support of mitochondria from cell bodies at great distances. Numerous neurodegenerative diseases are associated with mitochondrial dysfunction, and yet how a neuron maintains a pool of properly sized, functionally sound mitochondria at the correct density throughout large stretches of axons in vivo remains enigmatic. Given that many molecules known for mitochondrial regulation were discovered in non-neuronal cells in an in vitro setting, whether these molecules can translate into in vivo mitochondrial regulation is an open and important question. In this thesis, I utilized the power of Drosophila melanogaster and its extensive toolbox developed by the fruit fly community to study how axonal mitochondria are regulated in vivo.
000009304 542__ $$fIn copyright - single owner
000009304 650__ $$aMitochondria$$022348
000009304 650__ $$aNeurodegenerative Diseases$$031750
000009304 650__ $$aMitophagy$$040211
000009304 650__ $$aEndosomal Sorting Complexes Required for Transport$$038727
000009304 6531_ $$amitochondrial biogenesis
000009304 6531_ $$atsg101 protein
000009304 691__ $$aSchool of Medicine$$041369
000009304 692__ $$aVollum Institute$$041509
000009304 7001_ $$aLin, Tzu-Huai
000009304 8564_ $$92104270a-816c-40be-a072-1ae270cb3425$$s43094147$$uhttps://digitalcollections.ohsu.edu/record/9304/files/Lin.TzuHuai.2021.pdf
000009304 905__ $$a/rest/prod/w0/89/2b/78/w0892b788
000009304 909CO $$ooai:digitalcollections.ohsu.edu:9304$$pstudent-work
000009304 980__ $$aTheses and Dissertations