TY  - GEN
N2  - The descending pain modulatory pathway exerts bidirectional control of ongoing nociceptive inputs traveling from the body to the brain. Despite a large body of work implicating the vlPAG in pain modulation, the neuron type specific activation by acute and persistent inflammation has not been identified. This hypothesis posits selective MOR expression on GABAergic interneurons, however, several studies have revealed less targeted MOR expression, prompting us to determine whether MOR expression maps onto physiologically distinct neuron types.
DO  - 10.6083/vd66w063w
DO  - DOI
AB  - The descending pain modulatory pathway exerts bidirectional control of ongoing nociceptive inputs traveling from the body to the brain. Despite a large body of work implicating the vlPAG in pain modulation, the neuron type specific activation by acute and persistent inflammation has not been identified. This hypothesis posits selective MOR expression on GABAergic interneurons, however, several studies have revealed less targeted MOR expression, prompting us to determine whether MOR expression maps onto physiologically distinct neuron types.
T1  - Defining physiological heterogeneity and opioid receptor regulation within the ventrolateral periaqueductal gray  provides a framework to better understand descending pain modulation
DA  - 2021
AU  - McPherson, Kylie B.
L1  - https://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9317
L4  - https://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
KW  - Pain Perception
KW  - Pain Management
KW  - Electrophysiology
KW  - neuroscience
TI  - Defining physiological heterogeneity and opioid receptor regulation within the ventrolateral periaqueductal gray  provides a framework to better understand descending pain modulation
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
ER  -