000009317 001__ 9317
000009317 005__ 20240124114321.0
000009317 0247_ $$2DOI$$a10.6083/vd66w063w
000009317 037__ $$aETD
000009317 245__ $$aDefining physiological heterogeneity and opioid receptor regulation within the ventrolateral periaqueductal gray  provides a framework to better understand descending pain modulation
000009317 260__ $$bOregon Health and Science University
000009317 269__ $$a2021
000009317 336__ $$aDissertation
000009317 502__ $$bPh.D.
000009317 520__ $$aThe descending pain modulatory pathway exerts bidirectional control of ongoing nociceptive inputs traveling from the body to the brain. Despite a large body of work implicating the vlPAG in pain modulation, the neuron type specific activation by acute and persistent inflammation has not been identified. This hypothesis posits selective MOR expression on GABAergic interneurons, however, several studies have revealed less targeted MOR expression, prompting us to determine whether MOR expression maps onto physiologically distinct neuron types.
000009317 542__ $$fIn copyright - single owner
000009317 650__ $$aPain Perception$$039340
000009317 650__ $$aPain Management$$039572
000009317 650__ $$aElectrophysiology$$018311
000009317 6531_ $$aneuroscience
000009317 691__ $$aSchool of Medicine$$041369
000009317 692__ $$aVollum Institute$$041509
000009317 7001_ $$aMcPherson, Kylie B.
000009317 8564_ $$9073d8f08-e325-473d-b785-be768d8e1599$$s5295312$$uhttps://digitalcollections.ohsu.edu/record/9317/files/McPherson.Kylie.2021.pdf
000009317 905__ $$a/rest/prod/vd/66/w0/63/vd66w063w
000009317 909CO $$ooai:digitalcollections.ohsu.edu:9317$$pstudent-work
000009317 980__ $$aTheses and Dissertations