TY  - THES
AB  - Obesity is a global health concern linked to chronic diseases such as diabetes, hypertension, and cancer, yet its underlying mechanisms remain unclear. Conjugated linoleic acid (CLA) has shown anti-obesity and anticancer effects in animal studies and increased lean body mass in humans. This randomized clinical trial examined the impact of CLA supplementation (placebo, 3.2 g/day, 6.4 g/day) over 12 weeks in 48 healthy obese adults on oxidative stress and inflammation markers. Outcomes included DNA damage, expression of oxidative stress response genes (Nrf2, SOD1), and serum CRP and IL-6 levels. Higher CLA doses were significantly associated with increased CRP (p = 0.007) and IL-6 (p = 0.02). These findings suggest CLA may elevate inflammatory markers, warranting further research into its role in obesity and disease risk.
AD  - Oregon Health and Science University
AU  - Phillips, Austin
DA  - 2013
DO  - 10.6083/M42805NS
DO  - DOI
ED  - Thuillier, Philippe
ED  - Mentor
ID  - 933
KW  - Oxidative Stress
KW  - Gene Expression
KW  - Inflammation
KW  - Obesity
KW  - Linoleic Acid
KW  - Adult
KW  - Disease Susceptibility
KW  - Chronic Disease
KW  - Linoleic Acids, Conjugated
L1  - https://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf
N2  - Obesity is a global health concern linked to chronic diseases such as diabetes, hypertension, and cancer, yet its underlying mechanisms remain unclear. Conjugated linoleic acid (CLA) has shown anti-obesity and anticancer effects in animal studies and increased lean body mass in humans. This randomized clinical trial examined the impact of CLA supplementation (placebo, 3.2 g/day, 6.4 g/day) over 12 weeks in 48 healthy obese adults on oxidative stress and inflammation markers. Outcomes included DNA damage, expression of oxidative stress response genes (Nrf2, SOD1), and serum CRP and IL-6 levels. Higher CLA doses were significantly associated with increased CRP (p = 0.007) and IL-6 (p = 0.02). These findings suggest CLA may elevate inflammatory markers, warranting further research into its role in obesity and disease risk.
PB  - Oregon Health and Science University
PY  - 2013
T1  - Analysis of the effect of conjugated linoleic acid on markers of oxidative stress and inflammation in obese individuals
TI  - Analysis of the effect of conjugated linoleic acid on markers of oxidative stress and inflammation in obese individuals
UR  - https://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf
Y1  - 2013
ER  -