000000933 001__ 933
000000933 005__ 20260120144840.0
000000933 0247_ $$2DOI$$a10.6083/M42805NS
000000933 037__ $$aETD
000000933 245__ $$aAnalysis of the effect of conjugated linoleic acid on markers of oxidative stress and inflammation in obese individuals
000000933 260__ $$bOregon Health and Science University
000000933 269__ $$a2013
000000933 336__ $$aThesis
000000933 502__ $$bM.P.H.
000000933 520__ $$aObesity is a global health concern linked to chronic diseases such as diabetes, hypertension, and cancer, yet its underlying mechanisms remain unclear. Conjugated linoleic acid (CLA) has shown anti-obesity and anticancer effects in animal studies and increased lean body mass in humans. This randomized clinical trial examined the impact of CLA supplementation (placebo, 3.2 g/day, 6.4 g/day) over 12 weeks in 48 healthy obese adults on oxidative stress and inflammation markers. Outcomes included DNA damage, expression of oxidative stress response genes (Nrf2, SOD1), and serum CRP and IL-6 levels. Higher CLA doses were significantly associated with increased CRP (p = 0.007) and IL-6 (p = 0.02). These findings suggest CLA may elevate inflammatory markers, warranting further research into its role in obesity and disease risk.
000000933 540__ $$fCC BY
000000933 542__ $$fIn copyright - single owner
000000933 650__ $$aOxidative Stress$$030758
000000933 650__ $$aGene Expression$$028717
000000933 650__ $$aInflammation$$020800
000000933 650__ $$aObesity$$023118
000000933 650__ $$aLinoleic Acid$$031877
000000933 650__ $$aAdult$$014319
000000933 650__ $$aDisease Susceptibility$$017935
000000933 650__ $$aChronic Disease$$016715
000000933 650__ $$aLinoleic Acids, Conjugated$$035444
000000933 691__ $$aSchool of Medicine$$041369
000000933 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000000933 7001_ $$aPhillips, Austin$$uOregon Health and Science University$$041354
000000933 7201_ $$aThuillier, Philippe$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000933 8564_ $$95e5729f6-a995-4601-ae00-2e4d776b8125$$s1572558$$uhttps://digitalcollections.ohsu.edu/record/933/files/936_etd.pdf$$ePublic$$2e233db2aee7fc3a03ba714523c7a11f1$$31
000000933 905__ $$a/rest/prod/f4/75/2g/74/f4752g745
000000933 909CO $$ooai:digitalcollections.ohsu.edu:933$$pstudent-work
000000933 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000933 980__ $$aTheses and Dissertations