@article{ETD,
      school = {Ph.D.},
      author = {Sayar, Zeynep},
      url = {http://digitalcollections.ohsu.edu/record/9380},
      title = {Multi-omic characterization of localized prostate cancer  and development of multiplex liquid biopsy assays for  accurate patient stratification},
      publisher = {Oregon Health and Science University},
      abstract = {Prostate cancer is the second most commonly diagnosed  cancer in men worldwide. This thesis leverages novel  single-cell epigenomic and proteomic approaches to aid in  the identification of precise subtypes of prostate tumors  that are organ-confined at the time of diagnosis. We first  utilize cyclic immunofluorescent imaging to profile the  spatial heterogeneity of prostate tumors and uncover  risk-level and Gleason Pattern specific cell types and  cellular interactions. Next, we perform single-cell ATAC  sequencing of the same tumors and identify unique genomic  regions associated with high-risk tumors and immune  response signatures associated with low-risk tumors.  Finally, we develop assays that enable multiplex imaging of  biomarkers isolated from low-volume liquid biopsy samples.  Our work uncovers unique cellular and molecular markers,  which hold the potential to become novel prognostic  factors, and presents a multiplex liquid biopsy approach  for the detection of prostate cancer for precise treatment  strategies.},
      number = {ETD},
      doi = {https://doi.org/10.6083/n583xv754},
      recid = {9380},
      address = {2021},
}