TY  - GEN
N2  - Ovarian teratoma, comprising cystic mature teratomas and malignant immature teratomas, is a common cancer of the female reproductive tract that tends to occur in young women, forms a relatively large tumor mass, and displays differentiated or primitive tissue from 2 or 3 germ cell layers. Ovarian teratomas contain highly heterogeneous cell morphology, may disseminate to distant tissues, and occur bilaterally in 10-15% of cases. By exome sequencing, we have found a unique tumor etiology that is defined by the absence of significant point mutations, but widespread copy-neutral loss of heterozygosity affecting thousands of genes in each tumor genome. We also utilize loss of heterozygosity patterns to infer the clonal relationship between morphologically contrasting regions of immature teratomas, and uncover strong evidence that failure of meiosis I, meiosis II, or whole genome duplication is the defining genetic event of ovarian teratoma.
DO  - 10.6083/td96k311g
DO  - DOI
AB  - Ovarian teratoma, comprising cystic mature teratomas and malignant immature teratomas, is a common cancer of the female reproductive tract that tends to occur in young women, forms a relatively large tumor mass, and displays differentiated or primitive tissue from 2 or 3 germ cell layers. Ovarian teratomas contain highly heterogeneous cell morphology, may disseminate to distant tissues, and occur bilaterally in 10-15% of cases. By exome sequencing, we have found a unique tumor etiology that is defined by the absence of significant point mutations, but widespread copy-neutral loss of heterozygosity affecting thousands of genes in each tumor genome. We also utilize loss of heterozygosity patterns to infer the clonal relationship between morphologically contrasting regions of immature teratomas, and uncover strong evidence that failure of meiosis I, meiosis II, or whole genome duplication is the defining genetic event of ovarian teratoma.
T1  - Allele-specific analysis of genomic data reveals novel cancer and IncRNA biology
DA  - 2021
AU  - Heskett, Michael B.
L1  - https://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 9398
L4  - https://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
KW  - Teratoma
KW  - DNA Replication Timing
KW  - Ovarian Neoplasms
KW  - Genetics
KW  - noncoding rna
TI  - Allele-specific analysis of genomic data reveals novel cancer and IncRNA biology
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
ER  -