000009398 001__ 9398
000009398 005__ 20240124114321.0
000009398 0247_ $$2DOI$$a10.6083/td96k311g
000009398 037__ $$aETD
000009398 245__ $$aAllele-specific analysis of genomic data reveals novel cancer and IncRNA biology
000009398 260__ $$bOregon Health and Science University
000009398 269__ $$a2021
000009398 336__ $$aDissertation
000009398 502__ $$bPh.D.
000009398 520__ $$aOvarian teratoma, comprising cystic mature teratomas and malignant immature teratomas, is a common cancer of the female reproductive tract that tends to occur in young women, forms a relatively large tumor mass, and displays differentiated or primitive tissue from 2 or 3 germ cell layers. Ovarian teratomas contain highly heterogeneous cell morphology, may disseminate to distant tissues, and occur bilaterally in 10-15% of cases. By exome sequencing, we have found a unique tumor etiology that is defined by the absence of significant point mutations, but widespread copy-neutral loss of heterozygosity affecting thousands of genes in each tumor genome. We also utilize loss of heterozygosity patterns to infer the clonal relationship between morphologically contrasting regions of immature teratomas, and uncover strong evidence that failure of meiosis I, meiosis II, or whole genome duplication is the defining genetic event of ovarian teratoma.
000009398 542__ $$fIn copyright - single owner
000009398 650__ $$aTeratoma$$026844
000009398 650__ $$aDNA Replication Timing$$035197
000009398 650__ $$aOvarian Neoplasms$$023386
000009398 650__ $$aGenetics$$019472
000009398 6531_ $$anoncoding rna
000009398 691__ $$aSchool of Medicine$$041369
000009398 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000009398 7001_ $$aHeskett, Michael B.
000009398 8564_ $$975025164-0666-4d59-aa8c-514f5a6dcb2f$$s3101246$$uhttps://digitalcollections.ohsu.edu/record/9398/files/Heskett.Michael.2021.pdf
000009398 905__ $$a/rest/prod/td/96/k3/11/td96k311g
000009398 909CO $$ooai:digitalcollections.ohsu.edu:9398$$pstudent-work
000009398 980__ $$aTheses and Dissertations