000000943 001__ 943
000000943 005__ 20251205130840.0
000000943 0247_ $$2DOI$$a10.6083/M4RR1W8Z
000000943 037__ $$aETD
000000943 245__ $$aEmotional processing and brain activity in youth at high risk for alcoholism
000000943 260__ $$bOregon Health and Science University
000000943 269__ $$a2013
000000943 336__ $$aDissertation
000000943 502__ $$bPh.D.
000000943 502__ $$gBehavioral & Systems Neuroscience
000000943 520__ $$aYouth with a family history of alcoholism (FHP) are at elevated risk for alcohol use disorders (AUDs) and may exhibit pre-morbid neural differences in emotion-cognition processing. This study compared FHP and family-history-negative (FHN) adolescents using behavioral emotion tasks, fMRI, and resting-state connectivity prior to heavy alcohol use. While behavioral performance was similar, FHP youth showed reduced activation to positive faces and weaker fronto-striatal engagement during cognitive control. Resting-state analyses revealed altered amygdala connectivity with prefrontal regions, linked to inhibitory control errors. These findings suggest atypical emotion-cognition circuitry in FHP youth may represent a neural risk phenotype for AUD development.
000000943 540__ $$fCC BY
000000943 542__ $$fIn copyright - single owner
000000943 650__ $$aAlcoholism$$014412
000000943 650__ $$aNervous System$$022807
000000943 650__ $$aNeuroimaging$$039660
000000943 650__ $$aPedigree$$023690
000000943 650__ $$aAdolescent$$014285
000000943 650__ $$aEmotions$$018360
000000943 650__ $$aAmygdala$$014642
000000943 650__ $$aCognition$$016868
000000943 650__ $$aGenealogy and Heraldry$$019440
000000943 650__ $$aMagnetic Resonance Imaging$$021747
000000943 6531_ $$aadolescence
000000943 691__ $$aSchool of Medicine$$041369
000000943 692__ $$aDepartment of Behavioral Neuroscience$$041394
000000943 7001_ $$aCservenka, Anita$$uOregon Health and Science University$$041354
000000943 7201_ $$aNagel, Bonnie$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000943 8564_ $$9ffc0e559-ce6c-4404-8665-1012ab00674c$$s2982497$$uhttps://digitalcollections.ohsu.edu/record/943/files/946_etd.pdf$$ePublic$$2172f0069d4ae09e2069285842592387f$$31
000000943 905__ $$a/rest/prod/3b/59/18/57/3b591857h
000000943 909CO $$ooai:digitalcollections.ohsu.edu:943$$pstudent-work
000000943 980__ $$aTheses and Dissertations