000009443 001__ 9443
000009443 005__ 20240124114322.0
000009443 0247_ $$2DOI$$a10.6083/0r9674565
000009443 037__ $$aETD
000009443 245__ $$aAssessing the role of the rodent prefrontal cortex in anxiety during reward seeking
000009443 260__ $$bOregon Health and Science University
000009443 269__ $$a2021
000009443 336__ $$aDissertation
000009443 502__ $$bPh.D.
000009443 520__ $$aThe primary focus of this dissertation was to develop methods to model learning to adjust action as a function of risk using rats to assess neural representations of actions in a state of learned approach-avoidance con?ict. Once the appropriate behavioral model was developed, I focused on involvement of the prefrontal cortex (PFC) in encoding key events in behaving male and female rats in part because: 1) con?ict is believed to engage higher level control processes which are a key function of the PFC, and 2) PFC dysfunction is a common observation across psychopathologies mentioned above (Balderston, Vytal, et al., 2017; Goldstein & Volkow, 2011; Han et al., 2016; Milad & Rauch, 2007).
000009443 542__ $$fIn copyright - single owner
000009443 650__ $$aAnxiety$$014946
000009443 650__ $$aPrefrontal Cortex$$029938
000009443 650__ $$aNeuroimaging$$039660
000009443 650__ $$aReward$$025422
000009443 650__ $$aMotivation$$022450
000009443 6531_ $$aconflict
000009443 6531_ $$aapproach-avoidance conflict
000009443 691__ $$aSchool of Medicine$$041369
000009443 692__ $$aDepartment of Behavioral Neuroscience$$041394
000009443 7001_ $$aJacobs, David S.
000009443 8564_ $$9b2e27971-a3ee-42e5-945e-1a3147273343$$s35368787$$uhttps://digitalcollections.ohsu.edu/record/9443/files/Jacobs.David.2021.pdf
000009443 905__ $$a/rest/prod/0r/96/74/56/0r9674565
000009443 909CO $$ooai:digitalcollections.ohsu.edu:9443$$pstudent-work
000009443 980__ $$aTheses and Dissertations