@article{ETD,
      school = {Ph.D.},
      author = {Hudson, Clayton W.},
      url = {http://digitalcollections.ohsu.edu/record/9447},
      title = {The role of calcium-binding protein 39 in colorectal  cancer},
      publisher = {Oregon Health and Science University},
      abstract = {Our lab recently identified radiation responsive microRNAs  (miRNA) in colorectal cancer (CRC). The most upregulated  candidate, miRNA 451a, inhibited tumor cell proliferation.  Gain-of-function experiments confirmed that miRNA 451a  regulates calcium-binding protein 39 (CAB39) ribonucleic  acid (RNA) and protein levels in CRC. CAB39 is an upstream  regulator of the liver kinase B1 (LKB1) and activated  protein kinase (AMPK) signaling pathway. Our analysis of  The Cancer Genome Atlas (TCGA) data revealed that CAB39 is  upregulated at the protein level in a substantial number of  CRC patients and correlates with worse overall survival. I  hypothesized that CAB39 may have tumor cell intrinsic and  extrinsic functions in the CRC tumor microenvironment.},
      number = {ETD},
      doi = {https://doi.org/10.6083/6682x457b},
      recid = {9447},
      address = {2022},
}