TY  - GEN
AB  - Our lab recently identified radiation responsive microRNAs (miRNA) in colorectal cancer (CRC). The most upregulated candidate, miRNA 451a, inhibited tumor cell proliferation. Gain-of-function experiments confirmed that miRNA 451a regulates calcium-binding protein 39 (CAB39) ribonucleic acid (RNA) and protein levels in CRC. CAB39 is an upstream regulator of the liver kinase B1 (LKB1) and activated protein kinase (AMPK) signaling pathway. Our analysis of The Cancer Genome Atlas (TCGA) data revealed that CAB39 is upregulated at the protein level in a substantial number of CRC patients and correlates with worse overall survival. I hypothesized that CAB39 may have tumor cell intrinsic and extrinsic functions in the CRC tumor microenvironment.
AU  - Hudson, Clayton W.
DA  - 2022
DO  - 10.6083/6682x457b
DO  - DOI
ID  - 9447
KW  - Apoptosis
KW  - Calcium-Binding Proteins
KW  - MicroRNAs
KW  - Colorectal Neoplasms
KW  - Tumor Microenvironment
KW  - cellular immunity
KW  - human
KW  - calcium binding protein 39
L1  - https://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
L2  - https://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
L4  - https://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
N2  - Our lab recently identified radiation responsive microRNAs (miRNA) in colorectal cancer (CRC). The most upregulated candidate, miRNA 451a, inhibited tumor cell proliferation. Gain-of-function experiments confirmed that miRNA 451a regulates calcium-binding protein 39 (CAB39) ribonucleic acid (RNA) and protein levels in CRC. CAB39 is an upstream regulator of the liver kinase B1 (LKB1) and activated protein kinase (AMPK) signaling pathway. Our analysis of The Cancer Genome Atlas (TCGA) data revealed that CAB39 is upregulated at the protein level in a substantial number of CRC patients and correlates with worse overall survival. I hypothesized that CAB39 may have tumor cell intrinsic and extrinsic functions in the CRC tumor microenvironment.
PB  - Oregon Health and Science University
PY  - 2022
T1  - The role of calcium-binding protein 39 in colorectal cancer
TI  - The role of calcium-binding protein 39 in colorectal cancer
UR  - https://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
Y1  - 2022
ER  -