000009447 001__ 9447
000009447 005__ 20240124114322.0
000009447 0247_ $$2DOI$$a10.6083/6682x457b
000009447 037__ $$aETD
000009447 245__ $$aThe role of calcium-binding protein 39 in colorectal cancer
000009447 260__ $$bOregon Health and Science University
000009447 269__ $$a2022
000009447 336__ $$aDissertation
000009447 502__ $$bPh.D.
000009447 520__ $$aOur lab recently identified radiation responsive microRNAs (miRNA) in colorectal cancer (CRC). The most upregulated candidate, miRNA 451a, inhibited tumor cell proliferation. Gain-of-function experiments confirmed that miRNA 451a regulates calcium-binding protein 39 (CAB39) ribonucleic acid (RNA) and protein levels in CRC. CAB39 is an upstream regulator of the liver kinase B1 (LKB1) and activated protein kinase (AMPK) signaling pathway. Our analysis of The Cancer Genome Atlas (TCGA) data revealed that CAB39 is upregulated at the protein level in a substantial number of CRC patients and correlates with worse overall survival. I hypothesized that CAB39 may have tumor cell intrinsic and extrinsic functions in the CRC tumor microenvironment.
000009447 542__ $$fIn copyright - single owner
000009447 650__ $$aApoptosis$$029778
000009447 650__ $$aCalcium-Binding Proteins$$015979
000009447 650__ $$aMicroRNAs$$034671
000009447 650__ $$aColorectal Neoplasms$$028197
000009447 650__ $$aTumor Microenvironment$$039473
000009447 6531_ $$acellular immunity
000009447 6531_ $$ahuman
000009447 6531_ $$acalcium binding protein 39
000009447 691__ $$aSchool of Medicine$$041369
000009447 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000009447 7001_ $$aHudson, Clayton W.
000009447 8564_ $$9638078e2-94b4-497d-b878-5ba026e173a6$$s3893876$$uhttps://digitalcollections.ohsu.edu/record/9447/files/Hudson.Clay.2022.pdf
000009447 905__ $$a/rest/prod/66/82/x4/57/6682x457b
000009447 909CO $$ooai:digitalcollections.ohsu.edu:9447$$pstudent-work
000009447 980__ $$aTheses and Dissertations