TY  - THES
AB  - The thalamus, a major subcortical structure, relays sensory and motor signals to the cortex and striatum. This study introduces a method for mapping thalamic projections to delineate nuclei based on connectivity patterns. Multi-color fluorescent proteins were stereotaxically injected into small thalamic cell subsets, and labeled brains were serially sectioned, imaged, and reconstructed into normalized 3D volumes using Matlab. Regions of interest in cortex and striatum were manually segmented, and injections were scored by anatomical connectivity. This mesoscopic connectome approach enables comprehensive visualization of long-range thalamic projections, providing a framework for structural parcellation and investigation of complex neural circuits.
AD  - Oregon Health and Science University
AU  - Kusefoglu, Deniz
DA  - 2013
DO  - 10.6083/M4H70CVN
DO  - DOI
ED  - Mao, Tianyi
ED  - Advisor
ID  - 945
KW  - Neocortex
KW  - Thalamus
KW  - Brain Mapping
KW  - Basal Ganglia
KW  - Thalamic Nuclei
L1  - https://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf
N2  - The thalamus, a major subcortical structure, relays sensory and motor signals to the cortex and striatum. This study introduces a method for mapping thalamic projections to delineate nuclei based on connectivity patterns. Multi-color fluorescent proteins were stereotaxically injected into small thalamic cell subsets, and labeled brains were serially sectioned, imaged, and reconstructed into normalized 3D volumes using Matlab. Regions of interest in cortex and striatum were manually segmented, and injections were scored by anatomical connectivity. This mesoscopic connectome approach enables comprehensive visualization of long-range thalamic projections, providing a framework for structural parcellation and investigation of complex neural circuits.
PB  - Oregon Health and Science University
PY  - 2013
T1  - Long-range thalamic projections to neocortex and basal ganglia: a model for the mesoscopic connectome
TI  - Long-range thalamic projections to neocortex and basal ganglia: a model for the mesoscopic connectome
UR  - https://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf
Y1  - 2013
ER  -