000000945 001__ 945
000000945 005__ 20260120144840.0
000000945 0247_ $$2DOI$$a10.6083/M4H70CVN
000000945 037__ $$aETD
000000945 245__ $$aLong-range thalamic projections to neocortex and basal ganglia: a model for the mesoscopic connectome
000000945 260__ $$bOregon Health and Science University
000000945 269__ $$a2013
000000945 336__ $$aThesis
000000945 502__ $$bM.S.
000000945 502__ $$gNeuroscience
000000945 520__ $$aThe thalamus, a major subcortical structure, relays sensory and motor signals to the cortex and striatum. This study introduces a method for mapping thalamic projections to delineate nuclei based on connectivity patterns. Multi-color fluorescent proteins were stereotaxically injected into small thalamic cell subsets, and labeled brains were serially sectioned, imaged, and reconstructed into normalized 3D volumes using Matlab. Regions of interest in cortex and striatum were manually segmented, and injections were scored by anatomical connectivity. This mesoscopic connectome approach enables comprehensive visualization of long-range thalamic projections, providing a framework for structural parcellation and investigation of complex neural circuits.
000000945 540__ $$fCC BY
000000945 542__ $$fIn copyright - single owner
000000945 650__ $$aNeocortex$$031708
000000945 650__ $$aThalamus$$026904
000000945 650__ $$aBrain Mapping$$015798
000000945 650__ $$aBasal Ganglia$$015374
000000945 650__ $$aThalamic Nuclei$$026903
000000945 691__ $$aSchool of Medicine$$041369
000000945 692__ $$aVollum Institute$$041509
000000945 7001_ $$aKusefoglu, Deniz$$uOregon Health and Science University$$041354
000000945 7201_ $$aMao, Tianyi$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor
000000945 8564_ $$9852a1a89-05c9-42ec-93e4-da123285c84b$$s10433497$$uhttps://digitalcollections.ohsu.edu/record/945/files/948_etd.pdf$$ePublic$$29f96275a6f641f0a7eec0997a44d6f5e$$31
000000945 905__ $$a/rest/prod/gx/41/mh/92/gx41mh92t
000000945 909CO $$ooai:digitalcollections.ohsu.edu:945$$pstudent-work
000000945 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000945 980__ $$aTheses and Dissertations