000009473 001__ 9473
000009473 005__ 20240124114322.0
000009473 0247_ $$2DOI$$a10.6083/x059c8007
000009473 037__ $$aETD
000009473 245__ $$aPlatelet function and interaction with the contact system of coagulation
000009473 260__ $$bOregon Health and Science University
000009473 269__ $$a2022
000009473 336__ $$aDissertation
000009473 502__ $$bPh.D.
000009473 520__ $$aThe prevention of bleeding and protection of the vascular wall integrity is mediated by the blood cells platelets and enzymatic coagulation reactions in a process called hemostasis. An imbalance in this intricate hemostatic interplay of platelets and coagulation enzymes will cause pathological thrombus formation and this may lead to cardiovascular diseases such as myocardial infarction, stroke, and venous thrombosis. The present research focuses on the role of platelets in providing a surface that support coagulation and function and how platelets activation states can be affected by interference of their signaling cascades by environmental and dietary components.
000009473 542__ $$fIn copyright - single owner
000009473 650__ $$aBlood Platelets$$015667
000009473 650__ $$aBlood Coagulation$$015652
000009473 650__ $$aBlood Cells$$015648
000009473 650__ $$aFactor XI$$018859
000009473 6531_ $$athc
000009473 6531_ $$aadamts13
000009473 691__ $$aSchool of Medicine$$041369
000009473 692__ $$aDepartment of Biomedical Engineering$$041397
000009473 7001_ $$aReitsma, Stephanie E.
000009473 8564_ $$92e828b57-dcf0-4c3d-af60-7876d1677a00$$s14617190$$uhttps://digitalcollections.ohsu.edu/record/9473/files/Reitsma.Stephanie.2022.pdf
000009473 905__ $$a/rest/prod/x0/59/c8/00/x059c8007
000009473 909CO $$ooai:digitalcollections.ohsu.edu:9473$$pstudent-work
000009473 980__ $$aTheses and Dissertations