000009480 001__ 9480
000009480 005__ 20240124114322.0
000009480 0247_ $$2DOI$$a10.6083/z603qz138
000009480 037__ $$aETD
000009480 245__ $$aAnti-CCR5 antibody for HIV prevention, treatment, and cure
000009480 260__ $$bOregon Health and Science University
000009480 269__ $$a2022
000009480 336__ $$aDissertation
000009480 502__ $$bPh.D.
000009480 520__ $$aIn the absence of a prophylactic vaccine and curative strategies, the daily use of antiretroviral therapy (ART) is essential for preventing and maintaining HIV infection. Although ART plays a vital role in decreasing the numbers of new infections and AIDS-related deaths, transforming this once deadly disease into a manageable condition, we are also observing an increase in global antiretroviral (ARV) drug resistance. Because ART requires daily oral use for a lifetime, suboptimal treatment adherence will accelerate the development of drug resistance. To combat this problem, multiple classes of ARV drugs with different mechanisms of action are being incorporated into first-line drug regimens; however, drug resistance against newer forms of ARV drugs will ultimately rise with increasing usage. To this end, investigating different drug targets with higher genetic barriers to resistance and drug formulations to allow for less frequent dosing will aid in the slowing of the HIV epidemic. This dissertation hypothesizes that an anti-CCR5 antibody Leronlimab (PRO 140; PA14) can phenocopy the natural resistance observed in homozygous CCR5D32 individuals to prevent viral acquisition and suppress viremia.
000009480 542__ $$fIn copyright - single owner
000009480 650__ $$aMacaca mulatta$$021724
000009480 650__ $$aHIV$$020258
000009480 650__ $$aCD4-Positive T-Lymphocytes$$028453
000009480 650__ $$aAcquired Immunodeficiency Syndrome$$014162
000009480 6531_ $$accr5
000009480 6531_ $$aantibody
000009480 6531_ $$areceptor occupancy
000009480 6531_ $$anonhuman primates
000009480 691__ $$aSchool of Medicine$$041369
000009480 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000009480 7001_ $$aChang, Xiao L.
000009480 8564_ $$97bf1f8fc-4bb5-40f9-9f45-96b6e7ef5617$$s16938255$$uhttps://digitalcollections.ohsu.edu/record/9480/files/Chang.Xiaolan.2022.pdf
000009480 905__ $$a/rest/prod/z6/03/qz/13/z603qz138
000009480 909CO $$ooai:digitalcollections.ohsu.edu:9480$$pstudent-work
000009480 980__ $$aTheses and Dissertations