Romine, Kyle Tyner, Jeffrey

epigenetics brd4 Standard of Care T-Lymphocytes T-Cell Exhaustion Leukemia, Myeloid, Acute 2022 2022 Acute Myeloid Leukemia (AML) is a genetically and phenotypically heterogeneous white blood cell cancer with a poor prognosis and limited therapeutic options. For many decades the current standard of care has been an intensive chemotherapy regimen, to which only a fraction of patients respond and are physically able to withstand. However, the advent of deep genetic sequencing has led to the discovery of a number of mutational lesions targetable by small-molecule inhibitors, which more patients can tolerate. This dissertation demonstrates that AML drives in vivo T cell exhaustion, which is coordinated by multiple T cell receptor (TCR) activated transcription factors and BET proteins. Oregon Health and Science University Dissertation 10.6083/z890rt88b https://digitalcollections.ohsu.edu/record/9487/files/Romine.Kyle.2022.pdf