000009491 001__ 9491
000009491 005__ 20251007005917.0
000009491 0247_ $$2DOI$$a10.6083/d504rk980
000009491 037__ $$aETD
000009491 245__ $$aA distinct subpopulation of melanopsin ganglion cells in the dorsal retina: photoreception, distribution, and central innervation
000009491 260__ $$bOregon Health and Science University
000009491 269__ $$a2022
000009491 336__ $$aDissertation
000009491 502__ $$bPh.D.
000009491 520__ $$aTechnological changes to modern society have lead to circadian misalignment in a  significant  portion  of  the  population,  resulting  in  numerous  metabolic,  sleep, and  mood  disorders.  This  dysfunction  is  due  to  alterations  in  the  vast  range  of biological  clocks  that  regulate  our  physiology. My thesis work has focused on the study of a previously undescribed subpopulation of ipRGCs. These cells form an evenly-spaced mosaic and are restricted to the dorsal retina, coding for luminance reflected off the ground. Although they share some morphological similarity with other ipRGCs, I demonstrate this subpopulation has unique central projects to areas of circadian pacemaking, and form the exclusive innervation to the supraoptic nucleus (SON-ipRGCs); a site involved in systemic fluid homeostasis, maternal behavior, and appetite.
000009491 542__ $$fIn copyright - single owner
000009491 650__ $$aBiological Clocks$$015560
000009491 650__ $$aSupraoptic Nucleus$$026637
000009491 650__ $$aRetinal Ganglion Cells$$025392
000009491 650__ $$aRetina$$025387
000009491 650__ $$aSleep$$026066
000009491 650__ $$aNervous System Physiological Phenomena$$022811
000009491 650__ $$aVision, Ocular$$027854
000009491 6531_ $$amelanopsin
000009491 6531_ $$acircadian
000009491 691__ $$aSchool of Medicine$$041369
000009491 692__ $$aDepartment of Physiology and Pharmacology$$041442
000009491 7001_ $$aBerry, Michael$$uOregon Health and Science University$$041354
000009491 7201_ $$aSivyer, Ben$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000009491 7201_ $$aSchultz, Carsten$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000009491 8564_ $$9928fada6-c8eb-46da-818b-14baf389fa2c$$s96277789$$uhttps://digitalcollections.ohsu.edu/record/9491/files/Berry.Michael.2022.pdf$$ePublic$$22cd07213be5516315bd5bf041e65d0ae$$31
000009491 905__ $$a/rest/prod/d5/04/rk/98/d504rk980
000009491 909CO $$ooai:digitalcollections.ohsu.edu:9491$$pstudent-work
000009491 980__ $$aTheses and Dissertations