TY  - GEN
AB  - Obesity increases both the incidence and severity of asthma, but the underlying mechanisms leading to the development of obesity-related asthma remain elusive. High insulin levels, a part of the metabolic dysfunction frequently present in obese individuals, increase the risk of asthma, indicating that increased insulin has a role in the pathophysiology of obesity-related asthma. In this dissertation I investigate the mechanisms underlying obesity-related asthma. The findings in this dissertation add to our understanding of the underlying mechanisms linking insulin with airway nerve changes and excessive bronchoconstriction. These results emphasize the need and suggest targets for novel therapeutics specific to obesity-related asthma for preventing and treating this disease.
AU  - Calco, Gina N.
DA  - 2022
DO  - 10.6083/474299826
DO  - DOI
ID  - 9495
KW  - Obesity
KW  - Asthma
KW  - Neuronal Plasticity
KW  - nerves
KW  - airway hyperreactivity
KW  - sensory nerves
L1  - https://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
L2  - https://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
L4  - https://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
N2  - Obesity increases both the incidence and severity of asthma, but the underlying mechanisms leading to the development of obesity-related asthma remain elusive. High insulin levels, a part of the metabolic dysfunction frequently present in obese individuals, increase the risk of asthma, indicating that increased insulin has a role in the pathophysiology of obesity-related asthma. In this dissertation I investigate the mechanisms underlying obesity-related asthma. The findings in this dissertation add to our understanding of the underlying mechanisms linking insulin with airway nerve changes and excessive bronchoconstriction. These results emphasize the need and suggest targets for novel therapeutics specific to obesity-related asthma for preventing and treating this disease.
PB  - Oregon Health and Science University
PY  - 2022
T1  - Nerve-mediated airway hyperreactivity in obesity-related asthma: the central role of elevated insulin
TI  - Nerve-mediated airway hyperreactivity in obesity-related asthma: the central role of elevated insulin
UR  - https://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
Y1  - 2022
ER  -