000009495 001__ 9495
000009495 005__ 20240124114323.0
000009495 0247_ $$2DOI$$a10.6083/474299826
000009495 037__ $$aETD
000009495 245__ $$aNerve-mediated airway hyperreactivity in obesity-related asthma: the central role of elevated insulin
000009495 260__ $$bOregon Health and Science University
000009495 269__ $$a2022
000009495 336__ $$aDissertation
000009495 502__ $$bPh.D.
000009495 520__ $$aObesity increases both the incidence and severity of asthma, but the underlying mechanisms leading to the development of obesity-related asthma remain elusive. High insulin levels, a part of the metabolic dysfunction frequently present in obese individuals, increase the risk of asthma, indicating that increased insulin has a role in the pathophysiology of obesity-related asthma. In this dissertation I investigate the mechanisms underlying obesity-related asthma. The findings in this dissertation add to our understanding of the underlying mechanisms linking insulin with airway nerve changes and excessive bronchoconstriction. These results emphasize the need and suggest targets for novel therapeutics specific to obesity-related asthma for preventing and treating this disease.
000009495 542__ $$fIn copyright - single owner
000009495 650__ $$aObesity$$023118
000009495 650__ $$aAsthma$$015168
000009495 650__ $$aNeuronal Plasticity$$022857
000009495 6531_ $$anerves
000009495 6531_ $$aairway hyperreactivity
000009495 6531_ $$asensory nerves
000009495 691__ $$aSchool of Medicine$$041369
000009495 692__ $$aDepartment of Physiology and Pharmacology$$041442
000009495 7001_ $$aCalco, Gina N.
000009495 8564_ $$91190dab6-eabc-4c05-a108-55595f9f4ba1$$s6449825$$uhttps://digitalcollections.ohsu.edu/record/9495/files/Calco.Gina.2022.pdf
000009495 905__ $$a/rest/prod/47/42/99/82/474299826
000009495 909CO $$ooai:digitalcollections.ohsu.edu:9495$$pstudent-work
000009495 980__ $$aTheses and Dissertations