@article{IR, author = {Chan, Amy and Grigsby, Kolter and Jensen, Bryan and Medrano, Joselinne and Ledford, Courtney and Ozburn, Angela}, url = {http://digitalcollections.ohsu.edu/record/9525}, title = {Whole-brain activity changes in male and female C57BL/6J mice following binge-like alcohol drinking}, publisher = {Oregon Health and Science University}, abstract = {Binge alcohol drinking is a risk factor for Alcohol Use Disorder (AUD), and though AUD diagnoses are more prevalent in men than women, the gap has recently narrowed. Drinking-in-the-dark (DID) task is a preclinical model for binge alcohol drinking where mice drink to intoxication during a 2-4-hour period. Sex-differences have been seen using the DID model, where female mice tend to drink more, and manipulations of nucleus accumbens core (NAc core) activity differentially impacts ethanol intake in males and females. My project seeks to understand this sex-difference by combining whole-brain c-Fos labeling, a proxy for neural activity, with an intra-NAc core viral retrograde tracer to identify projections to the NAc core that are engaged following binge-like drinking.}, number = {IR}, doi = {https://doi.org/10.6083/zw12z609p}, recid = {9525}, address = {2022}, }