TY  - GEN
N2  - Binge alcohol drinking is a risk factor for Alcohol Use Disorder (AUD), and though AUD diagnoses are more prevalent in men than women, the gap has recently narrowed. Drinking-in-the-dark (DID) task is a preclinical model for binge alcohol drinking where mice drink to intoxication during a 2-4-hour period. Sex-differences have been seen using the DID model, where female mice tend to drink more, and manipulations of nucleus accumbens core (NAc core) activity differentially impacts ethanol intake in males and females. My project seeks to understand this sex-difference by combining whole-brain c-Fos labeling, a proxy for neural activity, with an intra-NAc core viral retrograde tracer to identify projections to the NAc core that are engaged following binge-like drinking.
DO  - 10.6083/zw12z609p
DO  - DOI
AB  - Binge alcohol drinking is a risk factor for Alcohol Use Disorder (AUD), and though AUD diagnoses are more prevalent in men than women, the gap has recently narrowed. Drinking-in-the-dark (DID) task is a preclinical model for binge alcohol drinking where mice drink to intoxication during a 2-4-hour period. Sex-differences have been seen using the DID model, where female mice tend to drink more, and manipulations of nucleus accumbens core (NAc core) activity differentially impacts ethanol intake in males and females. My project seeks to understand this sex-difference by combining whole-brain c-Fos labeling, a proxy for neural activity, with an intra-NAc core viral retrograde tracer to identify projections to the NAc core that are engaged following binge-like drinking.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Whole-brain activity changes in male and female  C57BL/6J mice following binge-like alcohol drinking
DA  - 2022
AU  - Chan, Amy
AU  - Grigsby, Kolter
AU  - Jensen, Bryan
AU  - Medrano, Joselinne
AU  - Ledford, Courtney
AU  - Ozburn, Angela
L1  - https://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf
PB  - Oregon Health and Science University
PY  - 2022
ID  - 9525
L4  - https://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf
KW  - Nucleus Accumbens
KW  - Alcoholism
KW  - Substance-Related Disorders
KW  - c-fos
KW  - circuitry
KW  - drinking-in-the-dark (did)
KW  - alcohol
TI  - Whole-brain activity changes in male and female  C57BL/6J mice following binge-like alcohol drinking
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf
ER  -