000009525 001__ 9525 000009525 005__ 20240418151754.0 000009525 0247_ $$2DOI$$a10.6083/zw12z609p 000009525 037__ $$aIR 000009525 245__ $$aWhole-brain activity changes in male and female C57BL/6J mice following binge-like alcohol drinking 000009525 260__ $$bOregon Health and Science University 000009525 269__ $$a2022 000009525 336__ $$aAbstract 000009525 520__ $$aBinge alcohol drinking is a risk factor for Alcohol Use Disorder (AUD), and though AUD diagnoses are more prevalent in men than women, the gap has recently narrowed. Drinking-in-the-dark (DID) task is a preclinical model for binge alcohol drinking where mice drink to intoxication during a 2-4-hour period. Sex-differences have been seen using the DID model, where female mice tend to drink more, and manipulations of nucleus accumbens core (NAc core) activity differentially impacts ethanol intake in males and females. My project seeks to understand this sex-difference by combining whole-brain c-Fos labeling, a proxy for neural activity, with an intra-NAc core viral retrograde tracer to identify projections to the NAc core that are engaged following binge-like drinking. 000009525 540__ $$fCC BY 000009525 542__ $$fIn copyright - joint owners 000009525 650__ $$aNucleus Accumbens$$023067 000009525 650__ $$aAlcoholism$$014412 000009525 650__ $$aSubstance-Related Disorders$$032029 000009525 6531_ $$ac-fos 000009525 6531_ $$acircuitry 000009525 6531_ $$adrinking-in-the-dark (did) 000009525 6531_ $$aalcohol 000009525 691__ $$aSchool of Medicine$$041369 000009525 692__ $$aDepartment of Behavioral Neuroscience$$041394 000009525 7001_ $$aChan, Amy$$uOregon Health and Science University$$041354 000009525 7001_ $$aGrigsby, Kolter$$uOregon Health and Science University$$041354 000009525 7001_ $$aJensen, Bryan$$uOregon Health and Science University$$041354 000009525 7001_ $$aMedrano, Joselinne$$uOregon Health and Science University$$041354 000009525 7001_ $$aLedford, Courtney$$uOregon Health and Science University$$041354 000009525 7001_ $$aOzburn, Angela$$uOregon Health and Science University$$041354 000009525 711__ $$aResearch Week$$uOregon Health and Science University$$d2022 000009525 8564_ $$959f40ab0-e9ed-4c4f-8940-f5f06fb1977b$$s73769$$uhttps://digitalcollections.ohsu.edu/record/9525/files/Chan-Amy-OHSU-ResearchWeek-2022.pdf 000009525 905__ $$a/rest/prod/zw/12/z6/09/zw12z609p 000009525 980__ $$aResearch Week