TY - GEN AB - Hypoxic ischemic encephalopathy (HIE) occurs in ~4 per 1000 live term births. Infants that receive current treatments may still develop adverse neurologic outcomes. Maternal gestational creatine supplementation has been proposed as a potential prophylactic neuroprotective therapy, with evidence of reduction in perinatal brain injury in rodent and sheep studies. The current study aims to characterize aspects of creatine synthesis, metabolism, and transport in gestational and neonatal tissues following maternal oral creatine supplementation. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Hudson Medical Research Institute AD - Deakin University AD - RMIT University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Dimagiba, Yvonne T. AU - Tripathy, Sudeshna AU - Ellery, Stacey J. AU - Snow, Rod J. AU - Walker, David W. AU - Sherman, Larry S. AU - Kelleher, Meredith A. DA - 2022 DO - 10.6083/hq37vp30d DO - DOI ID - 9529 KW - Creatine KW - Cerebral Palsy KW - Pregnancy KW - Premature Birth KW - Hypoxia-Ischemia, Brain KW - Hypoxia, Brain KW - hypoxic-ischemic encephalopathy L1 - https://digitalcollections.ohsu.edu/record/9529/files/Dimagiba-Yvonne-OHSU-ResearchWeek-2022.pdf L2 - https://digitalcollections.ohsu.edu/record/9529/files/Dimagiba-Yvonne-OHSU-ResearchWeek-2022.pdf L4 - https://digitalcollections.ohsu.edu/record/9529/files/Dimagiba-Yvonne-OHSU-ResearchWeek-2022.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/9529/files/Dimagiba-Yvonne-OHSU-ResearchWeek-2022.pdf N2 - Hypoxic ischemic encephalopathy (HIE) occurs in ~4 per 1000 live term births. Infants that receive current treatments may still develop adverse neurologic outcomes. Maternal gestational creatine supplementation has been proposed as a potential prophylactic neuroprotective therapy, with evidence of reduction in perinatal brain injury in rodent and sheep studies. The current study aims to characterize aspects of creatine synthesis, metabolism, and transport in gestational and neonatal tissues following maternal oral creatine supplementation. PB - Oregon Health and Science University PY - 2022 T1 - Maternal and perinatal outcomes of maternal creatine supplementation as a therapy for neonatal encephalopathy TI - Maternal and perinatal outcomes of maternal creatine supplementation as a therapy for neonatal encephalopathy UR - https://digitalcollections.ohsu.edu/record/9529/files/Dimagiba-Yvonne-OHSU-ResearchWeek-2022.pdf Y1 - 2022 ER -