@article{IR,
      author = {Guimaraes, Genine MF and Logan, MG and Icimoto, MY and  Patty, S. and Pfeifer, CC},
      url = {http://digitalcollections.ohsu.edu/record/9536},
      title = {Evaluation of the ability of a reversible switching  molecule to attack and defend against bacteria},
      publisher = {Oregon Health and Science University},
      abstract = {Biofilm colonization on biomedically-relevant surfaces is  one of the major causes leading to reinfection, including  in dental restorations. Every time a dental filling is  replaced, more tooth structure is lost, complicating  prognosis and increasing the chance for more serious  systemic infections. The existing antifouling and/or  antimicrobial materials are efficient in either preventing  attachment or killing the bacteria, but much more effective  protection could be achieved if both properties were  combined. Thus, our goal was to take advantage of natural  pH variations in the oral cavity to design a reversible  molecule (carboxy betaine - CB), alternatingly existing in  two chemical states: an antibacterial quaternary ammonium  cation (through acid-catalyzed ring closure, CB-Ring), and  an antifouling linear zwitterion, CB-OH.},
      number = {IR},
      doi = {https://doi.org/10.6083/9s161698m},
      recid = {9536},
      address = {2022},
}