TY - GEN AB - Biofilm colonization on biomedically-relevant surfaces is one of the major causes leading to reinfection, including in dental restorations. Every time a dental filling is replaced, more tooth structure is lost, complicating prognosis and increasing the chance for more serious systemic infections. The existing antifouling and/or antimicrobial materials are efficient in either preventing attachment or killing the bacteria, but much more effective protection could be achieved if both properties were combined. Thus, our goal was to take advantage of natural pH variations in the oral cavity to design a reversible molecule (carboxy betaine - CB), alternatingly existing in two chemical states: an antibacterial quaternary ammonium cation (through acid-catalyzed ring closure, CB-Ring), and an antifouling linear zwitterion, CB-OH. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Guimaraes, Genine MF AU - Logan, MG AU - Icimoto, MY AU - Patty, S. AU - Pfeifer, CC DA - 2022 DO - 10.6083/9s161698m DO - DOI ID - 9536 KW - surface chemistry KW - antimicrobial activity KW - switchable molecules KW - dental restoration KW - biofilm colonization KW - dental filling L1 - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf L2 - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf L4 - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf N2 - Biofilm colonization on biomedically-relevant surfaces is one of the major causes leading to reinfection, including in dental restorations. Every time a dental filling is replaced, more tooth structure is lost, complicating prognosis and increasing the chance for more serious systemic infections. The existing antifouling and/or antimicrobial materials are efficient in either preventing attachment or killing the bacteria, but much more effective protection could be achieved if both properties were combined. Thus, our goal was to take advantage of natural pH variations in the oral cavity to design a reversible molecule (carboxy betaine - CB), alternatingly existing in two chemical states: an antibacterial quaternary ammonium cation (through acid-catalyzed ring closure, CB-Ring), and an antifouling linear zwitterion, CB-OH. PB - Oregon Health and Science University PY - 2022 T1 - Evaluation of the ability of a reversible switching molecule to attack and defend against bacteria TI - Evaluation of the ability of a reversible switching molecule to attack and defend against bacteria UR - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf Y1 - 2022 ER -