TY  - GEN
N2  - Biofilm colonization on biomedically-relevant surfaces is one of the major causes leading to reinfection, including in dental restorations. Every time a dental filling is replaced, more tooth structure is lost, complicating prognosis and increasing the chance for more serious systemic infections. The existing antifouling and/or antimicrobial materials are efficient in either preventing attachment or killing the bacteria, but much more effective protection could be achieved if both properties were combined. Thus, our goal was to take advantage of natural pH variations in the oral cavity to design a reversible molecule (carboxy betaine - CB), alternatingly existing in two chemical states: an antibacterial quaternary ammonium cation (through acid-catalyzed ring closure, CB-Ring), and an antifouling linear zwitterion, CB-OH.
DO  - 10.6083/9s161698m
DO  - DOI
AB  - Biofilm colonization on biomedically-relevant surfaces is one of the major causes leading to reinfection, including in dental restorations. Every time a dental filling is replaced, more tooth structure is lost, complicating prognosis and increasing the chance for more serious systemic infections. The existing antifouling and/or antimicrobial materials are efficient in either preventing attachment or killing the bacteria, but much more effective protection could be achieved if both properties were combined. Thus, our goal was to take advantage of natural pH variations in the oral cavity to design a reversible molecule (carboxy betaine - CB), alternatingly existing in two chemical states: an antibacterial quaternary ammonium cation (through acid-catalyzed ring closure, CB-Ring), and an antifouling linear zwitterion, CB-OH.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Evaluation of the ability of a reversible switching molecule to attack and defend against bacteria
DA  - 2022
AU  - Guimaraes, Genine MF
AU  - Logan, MG
AU  - Icimoto, MY
AU  - Patty, S.
AU  - Pfeifer, CC
L1  - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2022
ID  - 9536
L4  - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
KW  - surface chemistry
KW  - antimicrobial activity
KW  - switchable molecules
KW  - dental restoration
KW  - biofilm colonization
KW  - dental filling
TI  - Evaluation of the ability of a reversible switching molecule to attack and defend against bacteria
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
ER  -