000009536 001__ 9536
000009536 005__ 20240405143251.0
000009536 0247_ $$2DOI$$a10.6083/9s161698m
000009536 037__ $$aIR
000009536 041__ $$aeng
000009536 245__ $$aEvaluation of the ability of a reversible switching molecule to attack and defend against bacteria
000009536 260__ $$bOregon Health and Science University
000009536 269__ $$a2022
000009536 336__ $$aAbstract
000009536 520__ $$aBiofilm colonization on biomedically-relevant surfaces is one of the major causes leading to reinfection, including in dental restorations. Every time a dental filling is replaced, more tooth structure is lost, complicating prognosis and increasing the chance for more serious systemic infections. The existing antifouling and/or antimicrobial materials are efficient in either preventing attachment or killing the bacteria, but much more effective protection could be achieved if both properties were combined. Thus, our goal was to take advantage of natural pH variations in the oral cavity to design a reversible molecule (carboxy betaine - CB), alternatingly existing in two chemical states: an antibacterial quaternary ammonium cation (through acid-catalyzed ring closure, CB-Ring), and an antifouling linear zwitterion, CB-OH.
000009536 536__ $$oNIH-NIDCR$$cR35-DE029083
000009536 540__ $$fCC BY
000009536 542__ $$fIn copyright - joint owners
000009536 6531_ $$asurface chemistry
000009536 6531_ $$aantimicrobial activity
000009536 6531_ $$aswitchable molecules
000009536 6531_ $$adental restoration
000009536 6531_ $$abiofilm colonization
000009536 6531_ $$adental filling
000009536 7001_ $$aGuimaraes, Genine MF$$uOregon Health and Science University$$041354
000009536 7001_ $$aLogan, MG$$uOregon Health and Science University$$041354
000009536 7001_ $$aIcimoto, MY$$uOregon Health and Science University$$041354
000009536 7001_ $$aPatty, S.$$uOregon Health and Science University$$041354
000009536 7001_ $$aPfeifer, CC$$uOregon Health and Science University$$041354
000009536 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009536 8564_ $$9a12f30ab-5081-4eb5-a480-d6badcbb3be8$$s357323$$uhttps://digitalcollections.ohsu.edu/record/9536/files/Guimaraes-Genine-OHSU-ResearchWeek-2022.pdf
000009536 905__ $$a/rest/prod/9s/16/16/98/9s161698m
000009536 980__ $$aResearch Week