@article{IR,
      author = {Dekker, Simone and Bambakidis, Ted and Williams, Aaron M.  and Biesterveld, Ben and Bhatti, Umar and Li, Yongqing and  Pickell, Zachary and Buller, Benjamin and Alam, Hasan B.},
      url = {http://digitalcollections.ohsu.edu/record/9537},
      title = {Early transfusion with mesenchymal stem cell derived  extracellular vesicles: a new transfusion strategy for  life-threatening hemorrhage and traumatic brain injury},
      publisher = {Oregon Health and Science University},
      abstract = {Life-threatening hemorrhage and traumatic brain injury  (TBI) have a significantly increasing global burden and  remain leading causes of preventable deaths. Effective  interventions may protect the brain against ongoing damage  and improve the long-term outcomes. A growing area of  interest is transfusion of cell-based therapies,  particularly with bone marrow-derived mesenchymal stem  cells (MSC). Transfusion using MSC derived extracellular  vesicles (EVs) have shown to improve neurologic outcomes in  animal models of life-threatening hemorrhage, stroke, and  TBI. However, the precise mechanisms remain poorly  characterized. In the present study, we aimed to elucidate  some of the key cerebral genes, pathways, and networks that  were modulated after transfusion of EVs in a porcine model  of hemorrhagic shock (HS) and TBI.},
      number = {IR},
      doi = {https://doi.org/10.6083/5712m7334},
      recid = {9537},
      address = {2022-04-07},
}