TY  - GEN
N2  - Life-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable deaths. Effective interventions may protect the brain against ongoing damage and improve the long-term outcomes. A growing area of interest is transfusion of cell-based therapies, particularly with bone marrow-derived mesenchymal stem cells (MSC). Transfusion using MSC derived extracellular vesicles (EVs) have shown to improve neurologic outcomes in animal models of life-threatening hemorrhage, stroke, and TBI. However, the precise mechanisms remain poorly characterized. In the present study, we aimed to elucidate some of the key cerebral genes, pathways, and networks that were modulated after transfusion of EVs in a porcine model of hemorrhagic shock (HS) and TBI.
DO  - 10.6083/5712m7334
DO  - DOI
AB  - Life-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable deaths. Effective interventions may protect the brain against ongoing damage and improve the long-term outcomes. A growing area of interest is transfusion of cell-based therapies, particularly with bone marrow-derived mesenchymal stem cells (MSC). Transfusion using MSC derived extracellular vesicles (EVs) have shown to improve neurologic outcomes in animal models of life-threatening hemorrhage, stroke, and TBI. However, the precise mechanisms remain poorly characterized. In the present study, we aimed to elucidate some of the key cerebral genes, pathways, and networks that were modulated after transfusion of EVs in a porcine model of hemorrhagic shock (HS) and TBI.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Early transfusion with mesenchymal stem cell derived extracellular vesicles: a new transfusion strategy for life-threatening hemorrhage and traumatic brain injury
DA  - 2022-04-07
AU  - Dekker, Simone
AU  - Bambakidis, Ted
AU  - Williams, Aaron M.
AU  - Biesterveld, Ben
AU  - Bhatti, Umar
AU  - Li, Yongqing
AU  - Pickell, Zachary
AU  - Buller, Benjamin
AU  - Alam, Hasan B.
L1  - https://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2022-04-07
ID  - 9537
L4  - https://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
KW  - Extracellular Vesicles
KW  - Brain Injuries, Traumatic
KW  - Stem Cells
KW  - Cerebral Hemorrhage, Traumatic
KW  - Cell- and Tissue-Based Therapy
KW  - Shock, Hemorrhagic
KW  - mesenchymal stem cells
TI  - Early transfusion with mesenchymal stem cell derived extracellular vesicles: a new transfusion strategy for life-threatening hemorrhage and traumatic brain injury
Y1  - 2022-04-07
L2  - https://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
ER  -