000009537 001__ 9537
000009537 005__ 20240404152702.0
000009537 0247_ $$2DOI$$a10.6083/5712m7334
000009537 037__ $$aIR
000009537 041__ $$aeng
000009537 245__ $$aEarly transfusion with mesenchymal stem cell derived extracellular vesicles: a new transfusion strategy for life-threatening hemorrhage and traumatic brain injury
000009537 260__ $$bOregon Health and Science University
000009537 269__ $$a2022-04-07
000009537 336__ $$aAbstract
000009537 520__ $$aLife-threatening hemorrhage and traumatic brain injury (TBI) have a significantly increasing global burden and remain leading causes of preventable deaths. Effective interventions may protect the brain against ongoing damage and improve the long-term outcomes. A growing area of interest is transfusion of cell-based therapies, particularly with bone marrow-derived mesenchymal stem cells (MSC). Transfusion using MSC derived extracellular vesicles (EVs) have shown to improve neurologic outcomes in animal models of life-threatening hemorrhage, stroke, and TBI. However, the precise mechanisms remain poorly characterized. In the present study, we aimed to elucidate some of the key cerebral genes, pathways, and networks that were modulated after transfusion of EVs in a porcine model of hemorrhagic shock (HS) and TBI.
000009537 540__ $$fCC BY
000009537 542__ $$fIn copyright - joint owners
000009537 650__ $$aExtracellular Vesicles$$011111
000009537 650__ $$aBrain Injuries, Traumatic$$011616
000009537 650__ $$aStem Cells$$026391
000009537 650__ $$aCerebral Hemorrhage, Traumatic$$032220
000009537 650__ $$aCell- and Tissue-Based Therapy$$040537
000009537 650__ $$aShock, Hemorrhagic$$025957
000009537 6531_ $$amesenchymal stem cells
000009537 691__ $$aSchool of Medicine$$041369
000009537 692__ $$aDepartment of Medicine$$041425
000009537 7001_ $$aDekker, Simone$$uOregon Health and Science University$$041354
000009537 7001_ $$aBambakidis, Ted$$uOregon Health and Science University$$041354
000009537 7001_ $$aWilliams, Aaron M.$$uOregon Health and Science University$$041354
000009537 7001_ $$aBiesterveld, Ben$$uOregon Health and Science University$$041354
000009537 7001_ $$aBhatti, Umar$$uOregon Health and Science University$$041354
000009537 7001_ $$aLi, Yongqing$$uOregon Health and Science University$$041354
000009537 7001_ $$aPickell, Zachary$$uOregon Health and Science University$$041354
000009537 7001_ $$aBuller, Benjamin$$uOregon Health and Science University$$041354
000009537 7001_ $$aAlam, Hasan B.$$uOregon Health and Science University$$041354
000009537 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009537 8564_ $$932e51a06-2b03-4864-98dc-0f33fec078ed$$s68384$$uhttps://digitalcollections.ohsu.edu/record/9537/files/Dekker-Simone-OHSU-ResearchWeek-2022.pdf
000009537 905__ $$a/rest/prod/57/12/m7/33/5712m7334
000009537 980__ $$aResearch Week