TY  - GEN
N2  - Age related sleep disruption and fragmentation are common in elderly populations and the amount of time spent in rapid eye movement (REM) sleep naturally declines with age. REM sleep is important for memory consolidation and this decline in REM may underlie aging-related cognitive decline. Many clinical conditions related to aging are the result of oxidative stress, and enhancing REM sleep has been found to have antioxidant effects. The application of extracts from the plant Centella asiatica reverses the effects of oxidative stress in rat, fruit fly, and sleep-deprived mouse models, however, little is known about how this substance affects sleep patterns in aged mice.
DO  - 10.6083/cn69m507m
DO  - DOI
AB  - Age related sleep disruption and fragmentation are common in elderly populations and the amount of time spent in rapid eye movement (REM) sleep naturally declines with age. REM sleep is important for memory consolidation and this decline in REM may underlie aging-related cognitive decline. Many clinical conditions related to aging are the result of oxidative stress, and enhancing REM sleep has been found to have antioxidant effects. The application of extracts from the plant Centella asiatica reverses the effects of oxidative stress in rat, fruit fly, and sleep-deprived mouse models, however, little is known about how this substance affects sleep patterns in aged mice.
AD  - OHSU & VA Portland Health Care System
AD  - OHSU & VA Portland Health Care System
AD  - OHSU & VA Portland Health Care System
AD  - OHSU & VA Portland Health Care System
AD  - OHSU & VA Portland Health Care System
AD  - OHSU & VA Portland Health Care System
T1  - Centella asiatica reverses age-related sleep deficits in an aged mouse model
DA  - 2022
AU  - Gutowsky, Katelyn
AU  - Wong, Claire
AU  - Tinsley, Carolyn E.
AU  - Soumyanath, Amala
AU  - Gray, Nora E.
AU  - Lim, Miranda M.
L1  - https://digitalcollections.ohsu.edu/record/9539/files/Gutowsky-Katelyn-OHSU-ResearchWeek-2022.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2022
ID  - 9539
L4  - https://digitalcollections.ohsu.edu/record/9539/files/Gutowsky-Katelyn-OHSU-ResearchWeek-2022.pdf
KW  - Oxidative Stress
KW  - Anxiety
KW  - Centella
KW  - Sleep Deprivation
KW  - Cognitive Dysfunction
KW  - Sleep, REM
KW  - EEG
KW  - neurodegeneration
KW  - cognitive decline
TI  - Centella asiatica reverses age-related sleep deficits in an aged mouse model
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9539/files/Gutowsky-Katelyn-OHSU-ResearchWeek-2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9539/files/Gutowsky-Katelyn-OHSU-ResearchWeek-2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9539/files/Gutowsky-Katelyn-OHSU-ResearchWeek-2022.pdf
ER  -