@article{IR,
      recid = {9542},
      author = {Garcia, Michelle and Guzman, Gaelen and Tafesse, Fikadu},
      title = {Investigating the roles of diacylglycerol during  Mycobacterium tuberculosis phagocytosis},
      publisher = {Oregon Health and Science University},
      address = {2022-04-08},
      number = {IR},
      abstract = {Mycobacterium tuberculosis (Mtb) remains a significant  global health threat, where an estimated 10 million  individuals suffered infection and around 1.4 million  people died in 2019 alone. Its success as a pathogen is in  part due to its ability to escape cellular immune responses  via several mechanisms, among which is the manipulation of  lipid metabolic pathways in the host. Previous studies have  demonstrated that membrane sphingolipids are implicated in  the first step of Mtb phagocytosis by different types of  phagocytic cells. This study will shed light on the exact  role of DAG during phagocytosis, such as determining  whether it is critical at the pathogen contact site,  phagocytic cup formation, or cellular entry. Understanding  sphingolipid dynamics during Mtb infection would allow us  to use novel approaches to combat this globally relevant  bacterium.},
      url = {http://digitalcollections.ohsu.edu/record/9542},
      doi = {https://doi.org/10.6083/dj52w556p},
}