TY  - GEN
AB  - Mycobacterium tuberculosis (Mtb) remains a significant global health threat, where an estimated 10 million individuals suffered infection and around 1.4 million people died in 2019 alone. Its success as a pathogen is in part due to its ability to escape cellular immune responses via several mechanisms, among which is the manipulation of lipid metabolic pathways in the host. Previous studies have demonstrated that membrane sphingolipids are implicated in the first step of Mtb phagocytosis by different types of phagocytic cells. This study will shed light on the exact role of DAG during phagocytosis, such as determining whether it is critical at the pathogen contact site, phagocytic cup formation, or cellular entry. Understanding sphingolipid dynamics during Mtb infection would allow us to use novel approaches to combat this globally relevant bacterium.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Garcia, Michelle
AU  - Guzman, Gaelen
AU  - Tafesse, Fikadu
DA  - 2022-04-08
DO  - 10.6083/dj52w556p
DO  - DOI
ID  - 9542
KW  - Mycobacterium tuberculosis
KW  - Phagocytosis
KW  - Sphingolipids
KW  - diacylglycerol
L1  - https://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
L2  - https://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
L4  - https://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
LK  - https://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
N2  - Mycobacterium tuberculosis (Mtb) remains a significant global health threat, where an estimated 10 million individuals suffered infection and around 1.4 million people died in 2019 alone. Its success as a pathogen is in part due to its ability to escape cellular immune responses via several mechanisms, among which is the manipulation of lipid metabolic pathways in the host. Previous studies have demonstrated that membrane sphingolipids are implicated in the first step of Mtb phagocytosis by different types of phagocytic cells. This study will shed light on the exact role of DAG during phagocytosis, such as determining whether it is critical at the pathogen contact site, phagocytic cup formation, or cellular entry. Understanding sphingolipid dynamics during Mtb infection would allow us to use novel approaches to combat this globally relevant bacterium.
PB  - Oregon Health and Science University
PY  - 2022-04-08
T1  - Investigating the roles of diacylglycerol during Mycobacterium tuberculosis phagocytosis
TI  - Investigating the roles of diacylglycerol during Mycobacterium tuberculosis phagocytosis
UR  - https://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
Y1  - 2022-04-08
ER  -