000009542 001__ 9542
000009542 005__ 20240410122610.0
000009542 0247_ $$2DOI$$a10.6083/dj52w556p
000009542 037__ $$aIR
000009542 245__ $$aInvestigating the roles of diacylglycerol during Mycobacterium tuberculosis phagocytosis
000009542 260__ $$bOregon Health and Science University
000009542 269__ $$a2022-04-08
000009542 336__ $$aAbstract
000009542 520__ $$aMycobacterium tuberculosis (Mtb) remains a significant global health threat, where an estimated 10 million individuals suffered infection and around 1.4 million people died in 2019 alone. Its success as a pathogen is in part due to its ability to escape cellular immune responses via several mechanisms, among which is the manipulation of lipid metabolic pathways in the host. Previous studies have demonstrated that membrane sphingolipids are implicated in the first step of Mtb phagocytosis by different types of phagocytic cells. This study will shed light on the exact role of DAG during phagocytosis, such as determining whether it is critical at the pathogen contact site, phagocytic cup formation, or cellular entry. Understanding sphingolipid dynamics during Mtb infection would allow us to use novel approaches to combat this globally relevant bacterium.
000009542 540__ $$fCC BY
000009542 542__ $$fIn copyright - joint owners
000009542 650__ $$aMycobacterium tuberculosis$$022570
000009542 650__ $$aPhagocytosis$$023897
000009542 650__ $$aSphingolipids$$026271
000009542 6531_ $$adiacylglycerol
000009542 691__ $$aSchool of Medicine$$041369
000009542 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000009542 7001_ $$aGarcia, Michelle$$uOregon Health and Science University$$041354
000009542 7001_ $$aGuzman, Gaelen$$uOregon Health and Science University$$041354
000009542 7001_ $$aTafesse, Fikadu$$uOregon Health and Science University$$041354
000009542 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009542 8564_ $$9870294a7-13cb-4c36-b1f7-2291c46fd152$$s83593$$uhttps://digitalcollections.ohsu.edu/record/9542/files/ResearchWeek2022_GarciaMichelle.pdf
000009542 905__ $$a/rest/prod/dj/52/w5/56/dj52w556p
000009542 980__ $$aResearch Week