TY - GEN AB - The GABRA2 gene encodes a subunit of a GABAA receptor found in the mesolimbic reward circuitry, and modulation of GABAA receptors by alcohol is hypothesized to contribute to the psychotropic properties of the drug. Linkage studies have found a significant correlation between a single nucleotide polymorphism (SNP, rs279858) in the GABRA2 gene and increased risk for alcohol use disorders (AUDs). AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Hart, Elijah R. AU - Gilbert, Sydney J. AU - Boyd, Stephen J. AU - Morales, Angelica M. AU - Mitchell, Suzanne H. AU - Nagel, Bonnie J. DA - 2022 DO - 10.6083/z316q237s DO - DOI ID - 9545 KW - Alcoholism KW - acute alcohol intoxication KW - functional connectivity KW - rs-fmri KW - mesolimbic reward circuitry KW - gabra2 L1 - https://digitalcollections.ohsu.edu/record/9545/files/Hart-Elijah-OHSU-ResearchWeek-2022.pdf L2 - https://digitalcollections.ohsu.edu/record/9545/files/Hart-Elijah-OHSU-ResearchWeek-2022.pdf L4 - https://digitalcollections.ohsu.edu/record/9545/files/Hart-Elijah-OHSU-ResearchWeek-2022.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/9545/files/Hart-Elijah-OHSU-ResearchWeek-2022.pdf N2 - The GABRA2 gene encodes a subunit of a GABAA receptor found in the mesolimbic reward circuitry, and modulation of GABAA receptors by alcohol is hypothesized to contribute to the psychotropic properties of the drug. Linkage studies have found a significant correlation between a single nucleotide polymorphism (SNP, rs279858) in the GABRA2 gene and increased risk for alcohol use disorders (AUDs). PB - Oregon Health and Science University PY - 2022 T1 - Associations between GABRA2 genetic variation, subjective response to acute alcohol intoxication, and the functional connectivity of the reward circuitry TI - Associations between GABRA2 genetic variation, subjective response to acute alcohol intoxication, and the functional connectivity of the reward circuitry UR - https://digitalcollections.ohsu.edu/record/9545/files/Hart-Elijah-OHSU-ResearchWeek-2022.pdf Y1 - 2022 ER -