TY  - GEN
N2  - Cardiorenal syndrome type 1 (CRS1) is acute kidney injury (AKI) due to rapid worsening of cardiac function, and is a common cause of AKI. Ischemic AKI and subsequent chronic kidney disease (CKD) is mainly investigated by using the model of renal pedicle clamp (ischemia-reperfusion injury: IRI) which models renal transplant warm ischemia. However, results from IRI do not mimic clinical CRS1. We have previously identified a cardiac-derived soluble factor, cardiac LIM protein (CSRP3), which mediates renal function. We hypothesized that the phenotype of AKI-CKD transition differs between animal models of systemic ischemia and renal-limited ischemia.
DO  - 10.6083/pr76f424d
DO  - DOI
AB  - Cardiorenal syndrome type 1 (CRS1) is acute kidney injury (AKI) due to rapid worsening of cardiac function, and is a common cause of AKI. Ischemic AKI and subsequent chronic kidney disease (CKD) is mainly investigated by using the model of renal pedicle clamp (ischemia-reperfusion injury: IRI) which models renal transplant warm ischemia. However, results from IRI do not mimic clinical CRS1. We have previously identified a cardiac-derived soluble factor, cardiac LIM protein (CSRP3), which mediates renal function. We hypothesized that the phenotype of AKI-CKD transition differs between animal models of systemic ischemia and renal-limited ischemia.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Cardiac arrest induced systemic ischemia alters phenotype of renal ischemia reperfusion injury
DA  - 2022-04-08
AU  - Funahashi, Yoshio
AU  - Groat, Tahnee
AU  - Hutchens, Michael
L1  - https://digitalcollections.ohsu.edu/record/9558/files/ResearchWeek2022-Abstract_funahashi.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2022-04-08
ID  - 9558
L4  - https://digitalcollections.ohsu.edu/record/9558/files/ResearchWeek2022-Abstract_funahashi.pdf
KW  - Acute Kidney Injury
KW  - aki-ckd transition
KW  - cardiorenal syndrome type 1
KW  - chronic kidney disease
TI  - Cardiac arrest induced systemic ischemia alters phenotype of renal ischemia reperfusion injury
Y1  - 2022-04-08
L2  - https://digitalcollections.ohsu.edu/record/9558/files/ResearchWeek2022-Abstract_funahashi.pdf
LK  - https://digitalcollections.ohsu.edu/record/9558/files/ResearchWeek2022-Abstract_funahashi.pdf
UR  - https://digitalcollections.ohsu.edu/record/9558/files/ResearchWeek2022-Abstract_funahashi.pdf
ER  -