@article{IR,
      author = {Bradford, Tanner and Martz, Kevin and Su, Xiao-Tong and  Maeoka, Yujiro and Sharma, Avika and McCormick, Jim and  Ellison, David and Nelson, Jonathan},
      url = {http://digitalcollections.ohsu.edu/record/9559},
      title = {Utilizing chemogenetic tools to study distal convoluted  tubule function},
      publisher = {Oregon Health and Science University},
      abstract = {Although it is the smallest segment of the nephron, the  distal convoluted tubule (DCT) plays an outsized role in  electrolyte homeostasis through regulation of several ions,  including sodium. In the DCT, sodium balance is primarily  determined by the regulation of the sodium-chloride  cotransporter (NCC). When phosphorylated, NCC reabsorbs  sodium away from the lumen of the nephron.  Dephosphorylation of NCC inactivates this reabsorption  resulting in increased sodium excretion. A similar effect  is leveraged by a common class of anti-hypertensive  medications called thiazides, which block NCC activity.  Gaining a better understanding of the molecular mechanism  by which NCC is regulated holds high clinical relevance to  several diseases including hypertension, FHHt, and Gitelman  syndrome. To investigate a novel mechanism that may  regulate NCC activity, we implemented a cell-specific  chemogenetic approach with Designer Receptors Exclusively  Activated by Designer Drugs (DREADD) technology.},
      number = {IR},
      doi = {https://doi.org/10.6083/rj430538n},
      recid = {9559},
      address = {2022-04-08},
}