000009569 001__ 9569
000009569 005__ 20240404151602.0
000009569 0247_ $$2DOI$$a10.6083/cn69m508w
000009569 037__ $$aIR
000009569 245__ $$aEarly phospho-signaling shifts in Smart BufferTM-preserved peripheral blood specimens in response to FLT3 inhibitor therapy
000009569 260__ $$bOregon Health and Science University
000009569 269__ $$a2022
000009569 336__ $$aAbstract
000009569 520__ $$aIdentification of druggable mutations in Acute Myeloid Leukemia (AML), such as FLT3-ITD, has led to the development of targeted therapies capable of out-performing cytotoxic chemotherapy. Despite early survival benefits, most patients with FLT3-ITD AML on trial with the FLT3 inhibitor (FLT3i) gilteritinib still develop treatment resistance. Critical readout of response to FLT3i as measured by phospho-signaling is missing for the majority of these patients. Here, we validated an innovative approach to obtaining these signatures by leveraging the Smart BufferTM preservation system for peripheral blood (PB) specimens integrated with phospho-mass cytometry as part of the ongoing BeatAML Trial.
000009569 540__ $$fCC BY
000009569 542__ $$fIn copyright - joint owners
000009569 650__ $$aNeoplasms$$022758
000009569 650__ $$aLeukemia, Myeloid, Acute$$028432
000009569 6531_ $$abeataml
000009569 6531_ $$aphospho-signaling
000009569 6531_ $$acytof
000009569 6531_ $$agilteritinib
000009569 691__ $$aSchool of Medicine$$041369
000009569 7001_ $$aNewman, Matthew T.$$uOregon Health and Science University$$041354
000009569 7001_ $$aBaker, Kristina$$uOregon Health and Science University$$041354
000009569 7001_ $$aJoshi, Sunil K.$$uOregon Health and Science University$$041354
000009569 7001_ $$aPittsenbarger, Janet$$uOregon Health and Science University$$041354
000009569 7001_ $$aTraer, Elie$$uOregon Health and Science University$$041354
000009569 7001_ $$aLind, Evan F.$$uOregon Health and Science University$$041354
000009569 7001_ $$aDruker, Brian J.$$uOregon Health and Science University$$041354
000009569 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009569 8564_ $$95dd66ab4-bb95-4401-9c6c-7245082f0fcb$$s164170$$uhttps://digitalcollections.ohsu.edu/record/9569/files/Newman-Matthew-OHSU-ResearchWeek-2022.pdf
000009569 905__ $$a/rest/prod/cn/69/m5/08/cn69m508w
000009569 980__ $$aResearch Week