TY  - GEN
N2  - White matter injury (WMI) contributes substantially to neurological impairment after ischemic stroke. However, WMI is often ignored in stroke therapeutic developments leading to unsuccessful translation of stroke research to clinical trials. Furthermore, the mechanism of WM injury changes with age which is one of the risk factors for stroke. There is a need for stroke interventions that protect WM in young and aging populations. We hypothesize that administration of CX-4945 protects WM and promotes behavioral improvement.
DO  - 10.6083/vq27zp127
DO  - DOI
AB  - White matter injury (WMI) contributes substantially to neurological impairment after ischemic stroke. However, WMI is often ignored in stroke therapeutic developments leading to unsuccessful translation of stroke research to clinical trials. Furthermore, the mechanism of WM injury changes with age which is one of the risk factors for stroke. There is a need for stroke interventions that protect WM in young and aging populations. We hypothesize that administration of CX-4945 protects WM and promotes behavioral improvement.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Casein kinase 2 inhibition protects young and aged  white matter against ischemia and improves behavioral functions in a subcortical white matter injury model
DA  - 2022
AU  - Nguyen, Hung
AU  - Zhu, Wenbin
AU  - Baltan, Selva
L1  - https://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2022
ID  - 9571
L4  - https://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
KW  - Stroke
KW  - Ischemia
KW  - Models, Animal
KW  - Casein Kinase II
KW  - white matter injury
TI  - Casein kinase 2 inhibition protects young and aged  white matter against ischemia and improves behavioral functions in a subcortical white matter injury model
Y1  - 2022
L2  - https://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
LK  - https://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
UR  - https://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
ER  -