000009571 001__ 9571
000009571 005__ 20240328104048.0
000009571 0247_ $$2DOI$$a10.6083/vq27zp127
000009571 037__ $$aIR
000009571 041__ $$aeng
000009571 245__ $$aCasein kinase 2 inhibition protects young and aged  white matter against ischemia and improves behavioral functions in a subcortical white matter injury model
000009571 260__ $$bOregon Health and Science University
000009571 269__ $$a2022
000009571 336__ $$aAbstract
000009571 520__ $$aWhite matter injury (WMI) contributes substantially to neurological impairment after ischemic stroke. However, WMI is often ignored in stroke therapeutic developments leading to unsuccessful translation of stroke research to clinical trials. Furthermore, the mechanism of WM injury changes with age which is one of the risk factors for stroke. There is a need for stroke interventions that protect WM in young and aging populations. We hypothesize that administration of CX-4945 protects WM and promotes behavioral improvement.
000009571 540__ $$fCC BY
000009571 542__ $$fIn copyright - joint owners
000009571 650__ $$aStroke$$032460
000009571 650__ $$aIschemia$$021046
000009571 650__ $$aModels, Animal$$033025
000009571 650__ $$aCasein Kinase II$$035958
000009571 6531_ $$awhite matter injury
000009571 691__ $$aSchool of Medicine$$041369
000009571 692__ $$aDepartment of Anesthesiology and Perioperative Medicine$$041393
000009571 7001_ $$aNguyen, Hung$$uOregon Health and Science University$$041354
000009571 7001_ $$aZhu, Wenbin$$uOregon Health and Science University$$041354
000009571 7001_ $$aBaltan, Selva$$uOregon Health and Science University$$041354
000009571 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009571 8564_ $$9308388f9-6ea3-4808-b29c-af320457fd1f$$s79285$$uhttps://digitalcollections.ohsu.edu/record/9571/files/Nguyen-Hung-OHSU-ResearchWeek-2022.pdf
000009571 905__ $$a/rest/prod/vq/27/zp/12/vq27zp127
000009571 980__ $$aResearch Week