000009581 001__ 9581
000009581 005__ 20240417140554.0
000009581 0247_ $$2DOI$$a10.6083/8049g5745
000009581 037__ $$aIR
000009581 041__ $$aeng
000009581 245__ $$aThe FLT3 F691L gatekeeper mutation promotes clinical resistance to Gilteritinib + Venetoclax in AML
000009581 260__ $$bOregon Health and Science University
000009581 269__ $$a2022
000009581 336__ $$aAbstract
000009581 520__ $$aAcute Myeloid Leukemia (AML) is an aggressive cancer with poor overall survival due to frequent relapse. FMS-like tyrosine kinase (FLT3) is the most commonly mutated genes in AML, and leads to higher relapse rates. Several FLT3 inhibitors have been developed, including gilteritinib. Our lab developed a two-step model of early and late resistance to study the mechanism of resistance and relapse to FLT3 inhibitors. Early resistant AML cells are dependent upon the marrow microenvironment for survival. Over time, intrinsic resistance allows independent growth and results in late resistance, leading to disease relapse.
000009581 540__ $$fCC BY
000009581 542__ $$fIn copyright - joint owners
000009581 650__ $$aLeukemia, Myeloid, Acute$$028432
000009581 6531_ $$aFLT3
000009581 6531_ $$amicroenvironment
000009581 6531_ $$aresistance
000009581 6531_ $$akinase inhibitors
000009581 692__ $$aOHSU Knight Cancer Institute$$041488
000009581 7001_ $$aSharzehi, Setareh$$uOregon Health and Science University$$041354
000009581 7001_ $$aJoshi, Sunil$$uOregon Health and Science University$$041354
000009581 7001_ $$aPittsenbarger, Janet$$uOregon Health and Science University$$041354
000009581 7001_ $$aBottomly, Daniel$$uOregon Health and Science University$$041354
000009581 7001_ $$aMcWeeney, Shannon$$uOregon Health and Science University$$041354
000009581 7001_ $$aTyner, Jeffrey W.$$uOregon Health and Science University$$041354
000009581 7001_ $$aTraer, Elie$$uOregon Health and Science University$$041354
000009581 711__ $$aResearch Week$$uOregon Health and Science University$$d2022
000009581 8564_ $$933138e92-e7e4-4060-ad46-1151d9c71b36$$s190329$$uhttps://digitalcollections.ohsu.edu/record/9581/files/Sharzehi-Setareh-OHSU-ResearchWeek-2022.pdf
000009581 905__ $$a/rest/prod/80/49/g5/74/8049g5745
000009581 980__ $$aResearch Week