TY  - GEN
AB  - The bone tissue is a complex nanocomposite, organized in a calcified extracellular matrix. Bone autografts remain the gold standard to treat traumatic bone injuries. However, autografts can increase morbidity of the patient?s donor site and has limited availability. On the other hand, bioprinted microgels are attractive biomaterials that offer injectability, tunability, and acts as a cargo to deliver therapeutic proteins and cells. Here, we aim to bioprint and mineralize cell-laden gelatin methacrylate (GelMA) microgels and test the effects of cryopreservation on cell viability for bone tissue engineering applications.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Sousa, Mauricio
AU  - Balbinot, Gabriela
AU  - Visalakshan, Rauhl
AU  - Subiah, Ramesh
AU  - Bertassoni, Luiz
DA  - 2022
DO  - 10.6083/8623hz558
DO  - DOI
ID  - 9584
KW  - Bioprinting
KW  - Bone Regeneration
KW  - Microgels
KW  - Osteocytes
KW  - mineralization
KW  - bone grafting
KW  - autograft
L1  - https://digitalcollections.ohsu.edu/record/9584/files/Sousa-Mauricio-OHSU-ResearchWeek-2022.pdf
L2  - https://digitalcollections.ohsu.edu/record/9584/files/Sousa-Mauricio-OHSU-ResearchWeek-2022.pdf
L4  - https://digitalcollections.ohsu.edu/record/9584/files/Sousa-Mauricio-OHSU-ResearchWeek-2022.pdf
LA  - eng
LK  - https://digitalcollections.ohsu.edu/record/9584/files/Sousa-Mauricio-OHSU-ResearchWeek-2022.pdf
N2  - The bone tissue is a complex nanocomposite, organized in a calcified extracellular matrix. Bone autografts remain the gold standard to treat traumatic bone injuries. However, autografts can increase morbidity of the patient?s donor site and has limited availability. On the other hand, bioprinted microgels are attractive biomaterials that offer injectability, tunability, and acts as a cargo to deliver therapeutic proteins and cells. Here, we aim to bioprint and mineralize cell-laden gelatin methacrylate (GelMA) microgels and test the effects of cryopreservation on cell viability for bone tissue engineering applications.
PB  - Oregon Health and Science University
PY  - 2022
T1  - Biomimetic nanoscale mineralization of bioprinted cell- laden microgels
TI  - Biomimetic nanoscale mineralization of bioprinted cell- laden microgels
UR  - https://digitalcollections.ohsu.edu/record/9584/files/Sousa-Mauricio-OHSU-ResearchWeek-2022.pdf
Y1  - 2022
ER  -