000009601 001__ 9601 000009601 005__ 20240404153555.0 000009601 0247_ $$2DOI$$a10.6083/0k225b88q 000009601 037__ $$aIR 000009601 041__ $$aeng 000009601 245__ $$aEffect of hormone replacement therapy on amyloid beta expression in the amygdala of aged Rhesus Macaques 000009601 260__ $$bOregon Health and Science University 000009601 269__ $$a2022-04-13 000009601 336__ $$aAbstract 000009601 520__ $$aAmyloid beta (A?) plaques represent one of the classic hallmarks of Alzheimer's disease (AD) pathology in the brain. In rhesus macaques, these plaques start becoming prominent when the animals are 20+ years old, although the underlying cause(s) are unclear. In the present study, our goal was to test the hypothesis that exposure to a Western-style, high-fat, high-sugar diet (WSD) and/or loss of ovarian steroids would advance the development of this histological marker of AD pathology. 000009601 540__ $$fCC BY 000009601 542__ $$fIn copyright - joint owners 000009601 650__ $$aAmyloid$$014645 000009601 650__ $$aAmygdala$$014642 000009601 650__ $$aHormone Replacement Therapy$$032264 000009601 650__ $$aDementia$$017461 000009601 650__ $$aAlzheimer Disease$$014513 000009601 650__ $$aEstrogens$$018663 000009601 650__ $$aMacaca mulatta$$021724 000009601 6531_ $$arhesus macaque 000009601 692__ $$aOregon National Primate Research Center$$041497 000009601 7001_ $$aAppleman, Maria-Luisa$$uOregon Health and Science University$$041354 000009601 7001_ $$aNilaver, Benjamin$$uOregon Health and Science University$$041354 000009601 7001_ $$aKohama, Steven G.$$uOregon Health and Science University$$041354 000009601 7001_ $$aUrbanski, Henryk F.$$uOregon Health and Science University$$041354 000009601 711__ $$aResearch Week$$uOregon Health and Science University$$d2022 000009601 8564_ $$98cdd515b-3ab0-428a-a0ed-69426b5de286$$s97350$$uhttps://digitalcollections.ohsu.edu/record/9601/files/ResearchWeek2022-Abstract_Luisa_Appleman.pdf 000009601 905__ $$a/rest/prod/0k/22/5b/88/0k225b88q 000009601 980__ $$aResearch Week