TY - GEN AB - Rod bipolar cells (RBCs) are the first interneurons in the primary rod visual pathway. RBCs transmit light-driven signals from rods in the outer retina and contribute to retinal output through downstream amacrine cells (ACs) in the inner retina. This thesis presents my work identifying and characterizing trophoblast glycoprotein (TPBG), a leucine-rich repeat transmembrane protein recently identified in RBCs. Similar leucine-rich repeat proteins in RBCs are essential for synaptic targeting, correct localization of signal transduction proteins, and regulating the RBC light response across different light intensities AU - Wakeham, Colin DA - 2022 DO - 10.6083/2r36tz28b DO - DOI ID - 9605 KW - Neurobiology KW - Retina KW - phosphoproteomics KW - protein kinase c alpha KW - amacrine cell KW - rod bipolar cell L1 - https://digitalcollections.ohsu.edu/record/9605/files/Wakeham.Colin.2022.pdf L2 - https://digitalcollections.ohsu.edu/record/9605/files/Wakeham.Colin.2022.pdf L4 - https://digitalcollections.ohsu.edu/record/9605/files/Wakeham.Colin.2022.pdf LK - https://digitalcollections.ohsu.edu/record/9605/files/Wakeham.Colin.2022.pdf N2 - Rod bipolar cells (RBCs) are the first interneurons in the primary rod visual pathway. RBCs transmit light-driven signals from rods in the outer retina and contribute to retinal output through downstream amacrine cells (ACs) in the inner retina. This thesis presents my work identifying and characterizing trophoblast glycoprotein (TPBG), a leucine-rich repeat transmembrane protein recently identified in RBCs. Similar leucine-rich repeat proteins in RBCs are essential for synaptic targeting, correct localization of signal transduction proteins, and regulating the RBC light response across different light intensities PB - Oregon Health and Science University PY - 2022 T1 - Characterization of trophoblast glycoprotein in retinal rod bipolar cells TI - Characterization of trophoblast glycoprotein in retinal rod bipolar cells UR - https://digitalcollections.ohsu.edu/record/9605/files/Wakeham.Colin.2022.pdf Y1 - 2022 ER -